Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway

The solution self-assembly of macromolecular amphiphiles offers an efficient, bottom-up strategy for producing well-defined nanocarriers, with applications ranging from drug delivery to nanoreactors. Typically, the generation of uniform nanocarrier architectures is controlled by processing methods t...

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Veröffentlicht in:Nat. Commun 2014-04, Vol.5 (1), p.3599-3599, Article 3599
Hauptverfasser: Kelley, Elizabeth G., Murphy, Ryan P., Seppala, Jonathan E., Smart, Thomas P., Hann, Sarah D., Sullivan, Millicent O., Epps, Thomas H.
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container_title Nat. Commun
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creator Kelley, Elizabeth G.
Murphy, Ryan P.
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Smart, Thomas P.
Hann, Sarah D.
Sullivan, Millicent O.
Epps, Thomas H.
description The solution self-assembly of macromolecular amphiphiles offers an efficient, bottom-up strategy for producing well-defined nanocarriers, with applications ranging from drug delivery to nanoreactors. Typically, the generation of uniform nanocarrier architectures is controlled by processing methods that rely on cosolvent mixtures. These preparation strategies hinge on the assumption that macromolecular solution nanostructures are kinetically stable following transfer from an organic/aqueous cosolvent into aqueous solution. Herein we demonstrate that unequivocal step-change shifts in micelle populations occur over several weeks following transfer into a highly selective solvent. The unexpected micelle growth evolves through a distinct bimodal distribution separated by multiple fusion events and critically depends on solution agitation. Notably, these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule and protein systems. Moreover, the non-equilibrium micelle size increase can have a major impact on the assumed stability of solution assemblies, for which performance is dictated by nanocarrier size and structure. Micelles find applications in areas such as drug delivery systems, and as such, the kinetic stability of these structures is of high interest. Here the authors show that individual block copolymer micelles can continue to evolve after transfer to a selective solvent.
doi_str_mv 10.1038/ncomms4599
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subjects 639/301/357/341
639/301/923/1028
639/638/541
Aqueous solutions
Butadienes
Chemical Phenomena
Equilibrium
Humanities and Social Sciences
Kinetics
Macromolecular Substances
Micelles
multidisciplinary
Nanostructures
Nanotechnology
Polyethylene
Polymers
Science
Science (multidisciplinary)
Solutions
Solvents
Surfactants
title Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway
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