A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran

MDM2 (Murine Double Minute2) is an oncoprotein that inhibits the P53 activity. Overexpression of MDM2 gene has been reported in several human tumors. In the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of MDM2 and susceptibility to...

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Veröffentlicht in:	Iranian biomedical journal 2014-10, Vol.18 (4), p.245-249
Hauptverfasser:	Hashemi, Mohammad, Omrani, Mohsen, Eskandari-Nasab, Ebrahim, Hasani, Seyed-Shahaboddin, Mashhadi, Mohammad Ali, Taheri, Mohsen
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease Humans INDEL Mutation Iran Models, Genetic Odds Ratio Original Polymorphism, Genetic Promoter Regions, Genetic Proto-Oncogene Proteins c-mdm2 - genetics Risk Factors
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