Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study
Objective Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function. Methods Participants of CARDIA were 18‐30 years when they underwent a baseline examination in 1985‐86. Seven follow‐up examinations were condu...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2014-11, Vol.22 (11), p.2434-2440 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Reis, Jared P. Allen, Norrina Gibbs, Bethany B. Gidding, Samuel S. Lee, Joyce M. Lewis, Cora E. Lima, Joao Lloyd‐Jones, Donald Loria, Catherine M. Powell‐Wiley, Tiffany M. Sharma, Shishir Wei, Gina Liu, Kiang |
| description | Objective
Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function.
Methods
Participants of CARDIA were 18‐30 years when they underwent a baseline examination in 1985‐86. Seven follow‐up examinations were conducted every 2‐5 years.
Results
Among 2,547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m−2) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (P |
| doi_str_mv | 10.1002/oby.20865 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4224979</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3666491111</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4795-2a0b1f528cedbbc5d383b49eba7932df5283a1461c99426d16892eecaeb0830e3</originalsourceid><addsrcrecordid>eNpdkctOGzEUhi1UxCXtghdAI3XDJuDbTMZdVAppuUhISBVIdGX5ckKMJuNgj4tmx6PXEyACVj4-_3du-hE6IPiYYExPvO6PKa6rcgvtEcHweMLE3ZdNXJNdtB_jA8a8wiXZQbu0JJQzTvfQ8zRGb5zqnG8LPy-6BRQW7gPA8FPWrXx0XV-o1hY2hQ3nNazzT65bFEtQMQWIg2BUsE6ZInYhmS5n16Xz1Jqh9EdxkwfMpn9-XU4zkmz_FW3PVRPh2-s7Qrdnv29mF-Or6_PL2fRqbPhElGOqsCbzktYGrNamtKxmmgvQaiIYtYPCFOEVMUJwWllS1YICGAUa1wwDG6GfL31XSS_BGmi7oBq5Cm6pQi-9cvKj0rqFvPf_JKeUizxkhI5eGwT_mCB2cumigaZRLfgUJakoxRXjuMzo90_og0-hzedlalIKQglmmTp8v9FmlTdzMnDyAjy5BvqNTrAcXJfZdbl2XV6f_l0H7D_kiqDp</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1675912103</pqid></control><display><type>article</type><title>Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Reis, Jared P. ; Allen, Norrina ; Gibbs, Bethany B. ; Gidding, Samuel S. ; Lee, Joyce M. ; Lewis, Cora E. ; Lima, Joao ; Lloyd‐Jones, Donald ; Loria, Catherine M. ; Powell‐Wiley, Tiffany M. ; Sharma, Shishir ; Wei, Gina ; Liu, Kiang</creator><creatorcontrib>Reis, Jared P. ; Allen, Norrina ; Gibbs, Bethany B. ; Gidding, Samuel S. ; Lee, Joyce M. ; Lewis, Cora E. ; Lima, Joao ; Lloyd‐Jones, Donald ; Loria, Catherine M. ; Powell‐Wiley, Tiffany M. ; Sharma, Shishir ; Wei, Gina ; Liu, Kiang</creatorcontrib><description>Objective
Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function.
Methods
Participants of CARDIA were 18‐30 years when they underwent a baseline examination in 1985‐86. Seven follow‐up examinations were conducted every 2‐5 years.
Results
Among 2,547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m−2) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (P < 0.001), LV volume (P < 0.001), LV mass‐to‐volume ratio (P < 0.001), left atrial dimension (P < 0.001), and ejection fraction (P < 0.05) after adjustment for duration of obesity and other risk factors. In contrast, a longer duration of overall obesity was associated with a greater LV mass (P = 0.003) and a trend for a lower ejection fraction (P = 0.07).
Conclusions
A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while the cumulative effects of a longer duration of overall obesity during young adulthood contribute to concentric remodeling predominantly by increasing LV mass.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20865</identifier><identifier>PMID: 25124342</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Abdomen ; Adiposity - physiology ; Adolescent ; Adult ; Adults ; Body Mass Index ; Cardiovascular disease ; Disease Progression ; Echocardiography ; Female ; Gastrointestinal surgery ; Heart attacks ; Heart failure ; Heart Ventricles - pathology ; Heart Ventricles - physiopathology ; Humans ; Longitudinal Studies ; Male ; Obesity ; Obesity - diagnostic imaging ; Obesity - pathology ; Obesity - physiopathology ; Organ Size ; Quality control ; Risk Factors ; Studies ; Ventricular Remodeling ; Waist Circumference ; Young Adult</subject><ispartof>Obesity (Silver Spring, Md.), 2014-11, Vol.22 (11), p.2434-2440</ispartof><rights>2014 The Obesity Society</rights><rights>2014 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Nov 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4795-2a0b1f528cedbbc5d383b49eba7932df5283a1461c99426d16892eecaeb0830e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20865$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20865$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25124342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reis, Jared P.</creatorcontrib><creatorcontrib>Allen, Norrina</creatorcontrib><creatorcontrib>Gibbs, Bethany B.</creatorcontrib><creatorcontrib>Gidding, Samuel S.</creatorcontrib><creatorcontrib>Lee, Joyce M.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><creatorcontrib>Lima, Joao</creatorcontrib><creatorcontrib>Lloyd‐Jones, Donald</creatorcontrib><creatorcontrib>Loria, Catherine M.</creatorcontrib><creatorcontrib>Powell‐Wiley, Tiffany M.</creatorcontrib><creatorcontrib>Sharma, Shishir</creatorcontrib><creatorcontrib>Wei, Gina</creatorcontrib><creatorcontrib>Liu, Kiang</creatorcontrib><title>Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function.
Methods
Participants of CARDIA were 18‐30 years when they underwent a baseline examination in 1985‐86. Seven follow‐up examinations were conducted every 2‐5 years.
Results
Among 2,547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m−2) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (P < 0.001), LV volume (P < 0.001), LV mass‐to‐volume ratio (P < 0.001), left atrial dimension (P < 0.001), and ejection fraction (P < 0.05) after adjustment for duration of obesity and other risk factors. In contrast, a longer duration of overall obesity was associated with a greater LV mass (P = 0.003) and a trend for a lower ejection fraction (P = 0.07).
Conclusions
A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while the cumulative effects of a longer duration of overall obesity during young adulthood contribute to concentric remodeling predominantly by increasing LV mass.</description><subject>Abdomen</subject><subject>Adiposity - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Disease Progression</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Heart Ventricles - pathology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Obesity</subject><subject>Obesity - diagnostic imaging</subject><subject>Obesity - pathology</subject><subject>Obesity - physiopathology</subject><subject>Organ Size</subject><subject>Quality control</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Ventricular Remodeling</subject><subject>Waist Circumference</subject><subject>Young Adult</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctOGzEUhi1UxCXtghdAI3XDJuDbTMZdVAppuUhISBVIdGX5ckKMJuNgj4tmx6PXEyACVj4-_3du-hE6IPiYYExPvO6PKa6rcgvtEcHweMLE3ZdNXJNdtB_jA8a8wiXZQbu0JJQzTvfQ8zRGb5zqnG8LPy-6BRQW7gPA8FPWrXx0XV-o1hY2hQ3nNazzT65bFEtQMQWIg2BUsE6ZInYhmS5n16Xz1Jqh9EdxkwfMpn9-XU4zkmz_FW3PVRPh2-s7Qrdnv29mF-Or6_PL2fRqbPhElGOqsCbzktYGrNamtKxmmgvQaiIYtYPCFOEVMUJwWllS1YICGAUa1wwDG6GfL31XSS_BGmi7oBq5Cm6pQi-9cvKj0rqFvPf_JKeUizxkhI5eGwT_mCB2cumigaZRLfgUJakoxRXjuMzo90_og0-hzedlalIKQglmmTp8v9FmlTdzMnDyAjy5BvqNTrAcXJfZdbl2XV6f_l0H7D_kiqDp</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Reis, Jared P.</creator><creator>Allen, Norrina</creator><creator>Gibbs, Bethany B.</creator><creator>Gidding, Samuel S.</creator><creator>Lee, Joyce M.</creator><creator>Lewis, Cora E.</creator><creator>Lima, Joao</creator><creator>Lloyd‐Jones, Donald</creator><creator>Loria, Catherine M.</creator><creator>Powell‐Wiley, Tiffany M.</creator><creator>Sharma, Shishir</creator><creator>Wei, Gina</creator><creator>Liu, Kiang</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201411</creationdate><title>Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study</title><author>Reis, Jared P. ; Allen, Norrina ; Gibbs, Bethany B. ; Gidding, Samuel S. ; Lee, Joyce M. ; Lewis, Cora E. ; Lima, Joao ; Lloyd‐Jones, Donald ; Loria, Catherine M. ; Powell‐Wiley, Tiffany M. ; Sharma, Shishir ; Wei, Gina ; Liu, Kiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4795-2a0b1f528cedbbc5d383b49eba7932df5283a1461c99426d16892eecaeb0830e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abdomen</topic><topic>Adiposity - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>Disease Progression</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Heart Ventricles - pathology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Obesity</topic><topic>Obesity - diagnostic imaging</topic><topic>Obesity - pathology</topic><topic>Obesity - physiopathology</topic><topic>Organ Size</topic><topic>Quality control</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Ventricular Remodeling</topic><topic>Waist Circumference</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reis, Jared P.</creatorcontrib><creatorcontrib>Allen, Norrina</creatorcontrib><creatorcontrib>Gibbs, Bethany B.</creatorcontrib><creatorcontrib>Gidding, Samuel S.</creatorcontrib><creatorcontrib>Lee, Joyce M.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><creatorcontrib>Lima, Joao</creatorcontrib><creatorcontrib>Lloyd‐Jones, Donald</creatorcontrib><creatorcontrib>Loria, Catherine M.</creatorcontrib><creatorcontrib>Powell‐Wiley, Tiffany M.</creatorcontrib><creatorcontrib>Sharma, Shishir</creatorcontrib><creatorcontrib>Wei, Gina</creatorcontrib><creatorcontrib>Liu, Kiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reis, Jared P.</au><au>Allen, Norrina</au><au>Gibbs, Bethany B.</au><au>Gidding, Samuel S.</au><au>Lee, Joyce M.</au><au>Lewis, Cora E.</au><au>Lima, Joao</au><au>Lloyd‐Jones, Donald</au><au>Loria, Catherine M.</au><au>Powell‐Wiley, Tiffany M.</au><au>Sharma, Shishir</au><au>Wei, Gina</au><au>Liu, Kiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2014-11</date><risdate>2014</risdate><volume>22</volume><issue>11</issue><spage>2434</spage><epage>2440</epage><pages>2434-2440</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function.
Methods
Participants of CARDIA were 18‐30 years when they underwent a baseline examination in 1985‐86. Seven follow‐up examinations were conducted every 2‐5 years.
Results
Among 2,547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m−2) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (P < 0.001), LV volume (P < 0.001), LV mass‐to‐volume ratio (P < 0.001), left atrial dimension (P < 0.001), and ejection fraction (P < 0.05) after adjustment for duration of obesity and other risk factors. In contrast, a longer duration of overall obesity was associated with a greater LV mass (P = 0.003) and a trend for a lower ejection fraction (P = 0.07).
Conclusions
A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while the cumulative effects of a longer duration of overall obesity during young adulthood contribute to concentric remodeling predominantly by increasing LV mass.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25124342</pmid><doi>10.1002/oby.20865</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2014-11, Vol.22 (11), p.2434-2440 |
| issn | 1930-7381 1930-739X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4224979 |
| source | MEDLINE; Access via Wiley Online Library; Wiley Online Library (Open Access Collection) |
| subjects | Abdomen Adiposity - physiology Adolescent Adult Adults Body Mass Index Cardiovascular disease Disease Progression Echocardiography Female Gastrointestinal surgery Heart attacks Heart failure Heart Ventricles - pathology Heart Ventricles - physiopathology Humans Longitudinal Studies Male Obesity Obesity - diagnostic imaging Obesity - pathology Obesity - physiopathology Organ Size Quality control Risk Factors Studies Ventricular Remodeling Waist Circumference Young Adult |
| title | Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study |
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