Platelets Direct Monocyte Differentiation Into Epithelioid-Like Multinucleated Giant Foam Cells With Suppressive Capacity Upon Mycobacterial Stimulation

Background. Epithelioid, foam, and multinucleated giant cells (MNGCs) are characteristics of tuberculosis granulomas, yet the precise genesis and functions of these transformed macrophages are unclear. We evaluated the role of platelets as drivers of macrophage transformation in mycobacterial infect...

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Veröffentlicht in:	The Journal of infectious diseases 2014-12, Vol.210 (11), p.1700-1710
Hauptverfasser:	Feng, Yonghong, Dorhoi, Anca, Mollenkopf, Hans-Joachim, Yin, Hongyun, Dong, Zhengwei, Mao, Ling, Zhou, Jun, Bi, Aixiao, Weber, Stephan, Maertzdorf, Jeroen, Chen, Gang, Chen, Yang, Kaufmann, Stefan H. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult BACTERIA Bacteriology Biological and medical sciences Biomarkers Blood Platelets - metabolism Coculture Techniques Epithelioid cells Female Foam cells Foam Cells - immunology Foam Cells - pathology Fundamental and applied biological sciences. Psychology Fungal infections Gene expression Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Granuloma Granuloma - genetics Granuloma - immunology Granuloma - microbiology Granuloma - pathology Humans Immunomodulation Infectious diseases Interleukin-10 - biosynthesis Lipopolysaccharides - immunology Macrophages Major and Brief Reports Male Medical sciences Microbiology Middle Aged Miscellaneous Monocytes Monocytes - immunology Monocytes - metabolism Monocytes - pathology Mycobacterium Mycobacterium - immunology Phagocytosis Platelet Activation Platelets Pulmonary tuberculosis Tuberculosis Tuberculosis - genetics Tuberculosis - immunology Tuberculosis - metabolism Tuberculosis - microbiology Tuberculosis - pathology
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