Muscle‐specific kinase (MuSK) autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction

Key points Myasthenic anti‐muscle‐specific‐kinase (MuSK) IgG was injected into mice to study its effect upon the MuSK signalling pathway and the homeostasis of postsynaptic acetylcholine receptor packing at the neuromuscular junction. Densities of MuSK, activated Src kinase, phosphorylated ACh recep...

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Veröffentlicht in:	The Journal of physiology 2014-07, Vol.592 (13), p.2881-2897
Hauptverfasser:	Ghazanfari, Nazanin, Morsch, Marco, Reddel, Stephen W., Liang, Simon X., Phillips, William D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - pharmacology Autoimmune diseases Female Humans Immunoglobulin G - pharmacology Mice Mice, Inbred C57BL Motor Endplate - drug effects Motor Endplate - metabolism Motor Endplate - physiology Muscle Proteins - metabolism Muscular system Myasthenia Gravis - immunology Neuroscience: Neurobiology of Disease Phosphorylation Protein Transport Receptor Protein-Tyrosine Kinases - immunology Receptor Protein-Tyrosine Kinases - metabolism Receptors, Cholinergic - metabolism Retention src-Family Kinases - metabolism
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