The promise of patient-derived xenografts: the best laid plans of mice and men

Compared with xenografts from previously established cell lines, patient-derived xenografts may more faithfully recapitulate the molecular diversity, cellular heterogeneity, and histology seen in patient tumors, although other limitations of murine models remain. The ability of these models to infor...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Clinical cancer research 2012-10, Vol.18 (19), p.5160-5162
Hauptverfasser:	Kopetz, Scott, Lemos, Robert, Powis, Garth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transformation, Neoplastic - drug effects Colorectal Neoplasms - drug therapy Drug Resistance, Neoplasm - genetics Female Humans Male Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!