The monocyte-macrophage axis in the intestine
•Mϕ are involved in gut homeostasis and the pathogenesis of intestinal inflammation.•Resident and proinflammatory intestinal Mϕ both derive from Ly6Chi blood monocytes.•Local environmental factors guide monocyte differentiation in the gut mucosa.•Monocyte differentiation is disrupted by inflammation...
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| Veröffentlicht in: | Cellular immunology 2014-09, Vol.291 (1-2), p.41-48 |
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| container_title | Cellular immunology |
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| creator | Bain, Calum C. Mowat, Allan McI |
| description | •Mϕ are involved in gut homeostasis and the pathogenesis of intestinal inflammation.•Resident and proinflammatory intestinal Mϕ both derive from Ly6Chi blood monocytes.•Local environmental factors guide monocyte differentiation in the gut mucosa.•Monocyte differentiation is disrupted by inflammation resulting in the accumulation of proinflammatory cells.
Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew. |
| doi_str_mv | 10.1016/j.cellimm.2014.03.012 |
| format | Article |
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Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/j.cellimm.2014.03.012</identifier><identifier>PMID: 24726741</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adaptive Immunity ; Animals ; Cell Differentiation - immunology ; Gastrointestinal Diseases - blood ; Gastrointestinal Diseases - immunology ; Homeostasis ; Humans ; Inflammation ; Inflammation - blood ; Inflammation - immunology ; Inflammation - pathology ; Intestinal Mucosa - immunology ; Intestinal Mucosa - pathology ; Intestine ; Macrophages ; Macrophages - cytology ; Macrophages - immunology ; Macrophages - pathology ; Mice ; Monocytes ; Monocytes - cytology ; Monocytes - immunology ; Monocytes - pathology</subject><ispartof>Cellular immunology, 2014-09, Vol.291 (1-2), p.41-48</ispartof><rights>2014 The Authors</rights><rights>Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.</rights><rights>2014 The Authors 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c655t-951e2d9ace10e1c6db6c8100a7ef39463da711df261d4295dbb63eb47a72f87f3</citedby><cites>FETCH-LOGICAL-c655t-951e2d9ace10e1c6db6c8100a7ef39463da711df261d4295dbb63eb47a72f87f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cellimm.2014.03.012$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24726741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bain, Calum C.</creatorcontrib><creatorcontrib>Mowat, Allan McI</creatorcontrib><title>The monocyte-macrophage axis in the intestine</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>•Mϕ are involved in gut homeostasis and the pathogenesis of intestinal inflammation.•Resident and proinflammatory intestinal Mϕ both derive from Ly6Chi blood monocytes.•Local environmental factors guide monocyte differentiation in the gut mucosa.•Monocyte differentiation is disrupted by inflammation resulting in the accumulation of proinflammatory cells.
Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew.</description><subject>Adaptive Immunity</subject><subject>Animals</subject><subject>Cell Differentiation - immunology</subject><subject>Gastrointestinal Diseases - blood</subject><subject>Gastrointestinal Diseases - immunology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestine</subject><subject>Macrophages</subject><subject>Macrophages - cytology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - pathology</subject><subject>Mice</subject><subject>Monocytes</subject><subject>Monocytes - cytology</subject><subject>Monocytes - immunology</subject><subject>Monocytes - pathology</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EgvL4CaAeuSTsOo5dX0Co4iUhcYGz5dgb6qpJSpwi-Pe4akFw4rSHnZ2Z_Rg7RcgRUF7Mc0eLRWianAOKHIockO-wEYKGjKMsdtkIACbZRAl9wA5jnAMgCg377IALxaUSOGLZ84zGTdd27nOgrLGu75Yz-0pj-xHiOLTjIe1DO1AcQkvHbK-2i0gn23nEXm5vnqf32ePT3cP0-jFzsiyHTJdI3GvrCIHQSV9JN0EAq6gutJCFtwrR11yiF1yXvqpkQZVQVvF6ouriiF1ufJerqiHvqB16uzDLPjS2_zSdDebvpg0z89q9G8FRYQnJ4Hxr0Hdvq1TeNCGugdmWulU0KLnWqkAQSVpupOn1GHuqf2IQzBq1mZstarNGbaAwCXW6O_vd8efqm20SXG0ElEi9B-pNdIFaRz705Abju_BPxBfrKJLe</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Bain, Calum C.</creator><creator>Mowat, Allan McI</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>The monocyte-macrophage axis in the intestine</title><author>Bain, Calum C. ; Mowat, Allan McI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c655t-951e2d9ace10e1c6db6c8100a7ef39463da711df261d4295dbb63eb47a72f87f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adaptive Immunity</topic><topic>Animals</topic><topic>Cell Differentiation - immunology</topic><topic>Gastrointestinal Diseases - blood</topic><topic>Gastrointestinal Diseases - immunology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestine</topic><topic>Macrophages</topic><topic>Macrophages - cytology</topic><topic>Macrophages - immunology</topic><topic>Macrophages - pathology</topic><topic>Mice</topic><topic>Monocytes</topic><topic>Monocytes - cytology</topic><topic>Monocytes - immunology</topic><topic>Monocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bain, Calum C.</creatorcontrib><creatorcontrib>Mowat, Allan McI</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bain, Calum C.</au><au>Mowat, Allan McI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The monocyte-macrophage axis in the intestine</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>291</volume><issue>1-2</issue><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>•Mϕ are involved in gut homeostasis and the pathogenesis of intestinal inflammation.•Resident and proinflammatory intestinal Mϕ both derive from Ly6Chi blood monocytes.•Local environmental factors guide monocyte differentiation in the gut mucosa.•Monocyte differentiation is disrupted by inflammation resulting in the accumulation of proinflammatory cells.
Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>24726741</pmid><doi>10.1016/j.cellimm.2014.03.012</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular immunology, 2014-09, Vol.291 (1-2), p.41-48 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptive Immunity Animals Cell Differentiation - immunology Gastrointestinal Diseases - blood Gastrointestinal Diseases - immunology Homeostasis Humans Inflammation Inflammation - blood Inflammation - immunology Inflammation - pathology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestine Macrophages Macrophages - cytology Macrophages - immunology Macrophages - pathology Mice Monocytes Monocytes - cytology Monocytes - immunology Monocytes - pathology |
| title | The monocyte-macrophage axis in the intestine |
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