Plakophilin 2 Affects Cell Migration by Modulating Focal Adhesion Dynamics and Integrin Protein Expression

Plakophilin 2 (PKP2), a desmosome component, modulates the activity and localization of the ce:small-caps GTPase RhoA at sites of cell–cell contact. PKP2 regulates cortical actin rearrangement during junction formation, and its loss is accompanied by an increase in actin stress fibers. We hypothesiz...

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Veröffentlicht in:	Journal of investigative dermatology 2014-01, Vol.134 (1), p.112-122
Hauptverfasser:	Koetsier, Jennifer L., Amargo, Evangeline V., Todorović, Viktor, Green, Kathleen J., Godsel, Lisa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Movement - physiology Desmosomes - physiology Epithelial Cells - cytology Epithelial Cells - physiology Focal Adhesions - physiology Humans Integrin beta1 - genetics Integrin beta1 - metabolism Integrin beta4 - genetics Integrin beta4 - metabolism Keratinocytes - cytology Keratinocytes - physiology Plakophilins - genetics Plakophilins - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Signal Transduction - physiology Wound Healing - physiology
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