Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity
A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobi...
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| Veröffentlicht in: | ACS nano 2014-07, Vol.8 (7), p.6748-6755 |
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| creator | Moyano, Daniel F Saha, Krishnendu Prakash, Gyan Yan, Bo Kong, Hao Yazdani, Mahdieh Rotello, Vincent M |
| description | A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface. |
| doi_str_mv | 10.1021/nn5006478 |
| format | Article |
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We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. 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These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface.</description><subject>Adsorption</subject><subject>Biological Transport</subject><subject>Blood Proteins - chemistry</subject><subject>Hemolysis - drug effects</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>MCF-7 Cells</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - metabolism</subject><subject>Nanoparticles - toxicity</subject><subject>Nanotechnology - methods</subject><subject>Surface Properties</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>N~.</sourceid><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhoMotn4c_AOyFw8eVpPN514EqdYKRS8VvIVsPmzKNlmyW6X_3pXqouBpBuaZZ5gXgDMErxAs0HUIFEJGuNgDY1RilkPBXveHnqIROGrbFYSUC84OwaggJUeMwzG4m6oqea06H0MWXTaJKQaVT5O12ZMKsVGp87q2bfbhu2W22ARV1TabbU2KzTJWXvtuewIOnKpbe_pdj8HL9H4xmeXz54fHye08VwTSLhfWMoqJc0yUJWFaEWw4pZQxrJgxjhjEES4EFkg5wRgVFeRal6YkBafO4GNws_M2m2ptjbahS6qWTfJrlbYyKi__ToJfyrf4LkmBqBCkF1zuBDrFtk3WDbsIyq8o5RBlz57_PjaQP9n1wMUOULqVq7hJof_9H9EnxAZ7YQ</recordid><startdate>20140722</startdate><enddate>20140722</enddate><creator>Moyano, Daniel F</creator><creator>Saha, Krishnendu</creator><creator>Prakash, Gyan</creator><creator>Yan, Bo</creator><creator>Kong, Hao</creator><creator>Yazdani, Mahdieh</creator><creator>Rotello, Vincent M</creator><general>American Chemical Society</general><scope>N~.</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140722</creationdate><title>Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity</title><author>Moyano, Daniel F ; Saha, Krishnendu ; Prakash, Gyan ; Yan, Bo ; Kong, Hao ; Yazdani, Mahdieh ; Rotello, Vincent M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a405t-8ee6534ff689946ca43d7555663a6ddf4d171328381af86658b07cc9d94275fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adsorption</topic><topic>Biological Transport</topic><topic>Blood Proteins - chemistry</topic><topic>Hemolysis - drug effects</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>MCF-7 Cells</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - metabolism</topic><topic>Nanoparticles - toxicity</topic><topic>Nanotechnology - methods</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moyano, Daniel F</creatorcontrib><creatorcontrib>Saha, Krishnendu</creatorcontrib><creatorcontrib>Prakash, Gyan</creatorcontrib><creatorcontrib>Yan, Bo</creatorcontrib><creatorcontrib>Kong, Hao</creatorcontrib><creatorcontrib>Yazdani, Mahdieh</creatorcontrib><creatorcontrib>Rotello, Vincent M</creatorcontrib><collection>American Chemical Society (ACS) Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moyano, Daniel F</au><au>Saha, Krishnendu</au><au>Prakash, Gyan</au><au>Yan, Bo</au><au>Kong, Hao</au><au>Yazdani, Mahdieh</au><au>Rotello, Vincent M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2014-07-22</date><risdate>2014</risdate><volume>8</volume><issue>7</issue><spage>6748</spage><epage>6755</epage><pages>6748-6755</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. 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| ispartof | ACS nano, 2014-07, Vol.8 (7), p.6748-6755 |
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| source | MEDLINE; ACS Publications |
| subjects | Adsorption Biological Transport Blood Proteins - chemistry Hemolysis - drug effects Hydrophobic and Hydrophilic Interactions MCF-7 Cells Nanoparticles - chemistry Nanoparticles - metabolism Nanoparticles - toxicity Nanotechnology - methods Surface Properties |
| title | Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity |
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