Role of the Fast Kinetics of Pyroglutamate-Modified Amyloid‑β Oligomers in Membrane Binding and Membrane Permeability

Membrane permeability to ions and small molecules is believed to be a critical step in the pathology of Alzheimer’s disease (AD). Interactions of oligomers formed by amyloid-β (Aβ) peptides with the plasma cell membrane are believed to play a fundamental role in the processes leading to membrane per...

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Veröffentlicht in:	Biochemistry (Easton) 2014-07, Vol.53 (28), p.4704-4714
Hauptverfasser:	Lee, Joon, Gillman, Alan L, Jang, Hyunbum, Ramachandran, Srinivasan, Kagan, Bruce L, Nussinov, Ruth, Teran Arce, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Cell Membrane - chemistry Cell Membrane - metabolism Cell Membrane Permeability Humans Kinetics Lipid Bilayers - chemistry Lipid Bilayers - metabolism Peptide Fragments - chemistry Peptide Fragments - metabolism
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