Automated Genome Mining of Ribosomal Peptide Natural Products

Ribosomally synthesized and posttranslationally modified peptides (RiPPs), especially from microbial sources, are a large group of bioactive natural products that are a promising source of new (bio)chemistry and bioactivity. In light of exponentially increasing microbial genome databases and improv...

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Veröffentlicht in:	ACS Chemical Biology, 9(7):1545-1551 9(7):1545-1551, 2014-07, Vol.9 (7), p.1545-1551
Hauptverfasser:	Mohimani, Hosein, Kersten, Roland D, Liu, Wei-Ting, Wang, Mingxun, Purvine, Samuel O, Wu, Si, Brewer, Heather M, Pasa-Tolic, Ljiljana, Bandeira, Nuno, Moore, Bradley S, Pevzner, Pavel A, Dorrestein, Pieter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological Products - metabolism Databases, Genetic Drug Discovery - methods Environmental Molecular Sciences Laboratory Genome, Bacterial Genomics - methods Molecular Sequence Data Multigene Family Peptides - chemistry Peptides - genetics Protein Processing, Post-Translational Proteomics - methods Ribosomes - chemistry Ribosomes - genetics Streptomyces - chemistry Streptomyces - genetics Tandem Mass Spectrometry - methods
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