Ovariectomy and genes encoding core circadian regulatory proteins in murine bone
Summary This study investigated the influence of ovarian hormone deficiency on core circadian regulatory protein (CCRP) in the context of bone loss. Our data suggest that ovarian hormone deficiency disrupts diurnal rhythmicity and CCRP expression in bone. Further studies should determine if chronobi...
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| Veröffentlicht in: | Osteoporosis international 2011-05, Vol.22 (5), p.1633-1639 |
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| creator | Smith, B. J. Sutton, G. M. Wu, X. Yu, G. Goh, B. C. Hebert, T. Pelled, G. Gazit, Z. Gazit, D. Butler, A. A. Gimble, J. M. |
| description | Summary
This study investigated the influence of ovarian hormone deficiency on core circadian regulatory protein (CCRP) in the context of bone loss. Our data suggest that ovarian hormone deficiency disrupts diurnal rhythmicity and CCRP expression in bone. Further studies should determine if chronobiology provides a novel therapeutic target for osteoporosis intervention.
Introduction
CCRP synchronize metabolic activities and display an oscillatory expression profile in murine bone. In vitro studies using bone marrow mesenchymal stromal/stem cells have demonstrated that the CCRP is present and can be regulated within osteoblast progenitors. In vivo studies have shown that the CCRP regulates bone mass via leptin/neuroendocrine pathways. The current study used an ovariectomized murine model to test the hypothesis that ovarian hormone deficiency is associated with either an attenuation and/or temporal phase shift of the CCRP oscillatory expression in bone and that these changes are correlated with the onset of osteoporosis.
Methods
Sham-operated controls and ovariectomized female C57BL/6 mice were euthanized at 4-h intervals 2 weeks post-operatively.
Results
Ovariectomy attenuated the oscillatory expression of CCRP mRNAs in the femur and vertebra relative to the controls and reduced the wheel-running activity profile.
Conclusion
Ovarian hormone deficiency modulates the expression profile of the CCRP with potential impact on bone marrow mesenchymal stem cell lineage commitment. |
| doi_str_mv | 10.1007/s00198-010-1325-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4215737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2315155031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-a63cc105e857358cfaa86d6a1ed83201f0922cc76d7fd873d52dae21f117f00f3</originalsourceid><addsrcrecordid>eNqFkV9rFDEUxYModl39AL5IEMSn0ZtkMpm8CFJaFQr1QcG3kCZ3xpTZZE1mCttPb5ZdWxXEpxDu75z75xDynMEbBqDeFgCm-wYYNExw2dw-ICvWCtFw3cmHZAVaqEa37NsJeVLKNVSN1uoxOeEgtWCdXJHPlzc2B3Rz2uyojZ6OGLFQjC75EEfqUkbqQnbWBxtpxnGZ7Jzyjm5zmjHEQkOkmyWHiPQqRXxKHg12Kvjs-K7J1_OzL6cfm4vLD59O3180TgqYG9sJ5xhI7KUSsneDtX3nO8vQ94IDG0Bz7pzqvBp8r4SX3FvkbGBMDQCDWJN3B9_tcrVB7zDO2U5mm8PG5p1JNpg_KzF8N2O6MS1ntaWqBq-PBjn9WLDMZhOKw2myEdNSjAYu6pXa_r9k3zGpueS6ki__Iq_TkmO9wx4C1bNquibsALmcSsk43A3NwOxzNYdcDez_NVdzWzUvft_2TvEryAq8OgK2ODsN2UYXyj3XgpZKscrxA1dqKY6Y7yf8d_efUpG8QA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>861078102</pqid></control><display><type>article</type><title>Ovariectomy and genes encoding core circadian regulatory proteins in murine bone</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Smith, B. J. ; Sutton, G. M. ; Wu, X. ; Yu, G. ; Goh, B. C. ; Hebert, T. ; Pelled, G. ; Gazit, Z. ; Gazit, D. ; Butler, A. A. ; Gimble, J. M.</creator><creatorcontrib>Smith, B. J. ; Sutton, G. M. ; Wu, X. ; Yu, G. ; Goh, B. C. ; Hebert, T. ; Pelled, G. ; Gazit, Z. ; Gazit, D. ; Butler, A. A. ; Gimble, J. M.</creatorcontrib><description>Summary
This study investigated the influence of ovarian hormone deficiency on core circadian regulatory protein (CCRP) in the context of bone loss. Our data suggest that ovarian hormone deficiency disrupts diurnal rhythmicity and CCRP expression in bone. Further studies should determine if chronobiology provides a novel therapeutic target for osteoporosis intervention.
Introduction
CCRP synchronize metabolic activities and display an oscillatory expression profile in murine bone. In vitro studies using bone marrow mesenchymal stromal/stem cells have demonstrated that the CCRP is present and can be regulated within osteoblast progenitors. In vivo studies have shown that the CCRP regulates bone mass via leptin/neuroendocrine pathways. The current study used an ovariectomized murine model to test the hypothesis that ovarian hormone deficiency is associated with either an attenuation and/or temporal phase shift of the CCRP oscillatory expression in bone and that these changes are correlated with the onset of osteoporosis.
Methods
Sham-operated controls and ovariectomized female C57BL/6 mice were euthanized at 4-h intervals 2 weeks post-operatively.
Results
Ovariectomy attenuated the oscillatory expression of CCRP mRNAs in the femur and vertebra relative to the controls and reduced the wheel-running activity profile.
Conclusion
Ovarian hormone deficiency modulates the expression profile of the CCRP with potential impact on bone marrow mesenchymal stem cell lineage commitment.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-010-1325-z</identifier><identifier>PMID: 20593165</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject>Animals ; Biological and medical sciences ; Bone marrow ; Circadian Rhythm - genetics ; Circadian Rhythm - physiology ; Circadian Rhythm Signaling Peptides and Proteins - biosynthesis ; Circadian Rhythm Signaling Peptides and Proteins - genetics ; Disease Models, Animal ; Diseases of the osteoarticular system ; Endocrinology ; Estrogens ; Estrogens - deficiency ; Estrogens - physiology ; Female ; Femur - metabolism ; Gene Expression Profiling - methods ; Gene Expression Regulation - physiology ; Genes ; Lumbar Vertebrae - metabolism ; Medical sciences ; Medicine ; Medicine & Public Health ; Mice ; Mice, Inbred C57BL ; Motor Activity - physiology ; Orthopedics ; Osteoporosis - genetics ; Osteoporosis - metabolism ; Osteoporosis - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; Ovariectomy ; Proteins ; Rheumatology ; RNA, Messenger - genetics ; Rodents ; Short Communication ; Stem cells ; Stress, Mechanical ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; X-Ray Microtomography - methods</subject><ispartof>Osteoporosis international, 2011-05, Vol.22 (5), p.1633-1639</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2010</rights><rights>2015 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2011</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2010 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-a63cc105e857358cfaa86d6a1ed83201f0922cc76d7fd873d52dae21f117f00f3</citedby><cites>FETCH-LOGICAL-c530t-a63cc105e857358cfaa86d6a1ed83201f0922cc76d7fd873d52dae21f117f00f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-010-1325-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-010-1325-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,782,786,887,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24095771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20593165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, B. J.</creatorcontrib><creatorcontrib>Sutton, G. M.</creatorcontrib><creatorcontrib>Wu, X.</creatorcontrib><creatorcontrib>Yu, G.</creatorcontrib><creatorcontrib>Goh, B. C.</creatorcontrib><creatorcontrib>Hebert, T.</creatorcontrib><creatorcontrib>Pelled, G.</creatorcontrib><creatorcontrib>Gazit, Z.</creatorcontrib><creatorcontrib>Gazit, D.</creatorcontrib><creatorcontrib>Butler, A. A.</creatorcontrib><creatorcontrib>Gimble, J. M.</creatorcontrib><title>Ovariectomy and genes encoding core circadian regulatory proteins in murine bone</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
This study investigated the influence of ovarian hormone deficiency on core circadian regulatory protein (CCRP) in the context of bone loss. Our data suggest that ovarian hormone deficiency disrupts diurnal rhythmicity and CCRP expression in bone. Further studies should determine if chronobiology provides a novel therapeutic target for osteoporosis intervention.
Introduction
CCRP synchronize metabolic activities and display an oscillatory expression profile in murine bone. In vitro studies using bone marrow mesenchymal stromal/stem cells have demonstrated that the CCRP is present and can be regulated within osteoblast progenitors. In vivo studies have shown that the CCRP regulates bone mass via leptin/neuroendocrine pathways. The current study used an ovariectomized murine model to test the hypothesis that ovarian hormone deficiency is associated with either an attenuation and/or temporal phase shift of the CCRP oscillatory expression in bone and that these changes are correlated with the onset of osteoporosis.
Methods
Sham-operated controls and ovariectomized female C57BL/6 mice were euthanized at 4-h intervals 2 weeks post-operatively.
Results
Ovariectomy attenuated the oscillatory expression of CCRP mRNAs in the femur and vertebra relative to the controls and reduced the wheel-running activity profile.
Conclusion
Ovarian hormone deficiency modulates the expression profile of the CCRP with potential impact on bone marrow mesenchymal stem cell lineage commitment.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian Rhythm Signaling Peptides and Proteins - biosynthesis</subject><subject>Circadian Rhythm Signaling Peptides and Proteins - genetics</subject><subject>Disease Models, Animal</subject><subject>Diseases of the osteoarticular system</subject><subject>Endocrinology</subject><subject>Estrogens</subject><subject>Estrogens - deficiency</subject><subject>Estrogens - physiology</subject><subject>Female</subject><subject>Femur - metabolism</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genes</subject><subject>Lumbar Vertebrae - metabolism</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Motor Activity - physiology</subject><subject>Orthopedics</subject><subject>Osteoporosis - genetics</subject><subject>Osteoporosis - metabolism</subject><subject>Osteoporosis - physiopathology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Ovariectomy</subject><subject>Proteins</subject><subject>Rheumatology</subject><subject>RNA, Messenger - genetics</subject><subject>Rodents</subject><subject>Short Communication</subject><subject>Stem cells</subject><subject>Stress, Mechanical</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>X-Ray Microtomography - methods</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkV9rFDEUxYModl39AL5IEMSn0ZtkMpm8CFJaFQr1QcG3kCZ3xpTZZE1mCttPb5ZdWxXEpxDu75z75xDynMEbBqDeFgCm-wYYNExw2dw-ICvWCtFw3cmHZAVaqEa37NsJeVLKNVSN1uoxOeEgtWCdXJHPlzc2B3Rz2uyojZ6OGLFQjC75EEfqUkbqQnbWBxtpxnGZ7Jzyjm5zmjHEQkOkmyWHiPQqRXxKHg12Kvjs-K7J1_OzL6cfm4vLD59O3180TgqYG9sJ5xhI7KUSsneDtX3nO8vQ94IDG0Bz7pzqvBp8r4SX3FvkbGBMDQCDWJN3B9_tcrVB7zDO2U5mm8PG5p1JNpg_KzF8N2O6MS1ntaWqBq-PBjn9WLDMZhOKw2myEdNSjAYu6pXa_r9k3zGpueS6ki__Iq_TkmO9wx4C1bNquibsALmcSsk43A3NwOxzNYdcDez_NVdzWzUvft_2TvEryAq8OgK2ODsN2UYXyj3XgpZKscrxA1dqKY6Y7yf8d_efUpG8QA</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Smith, B. J.</creator><creator>Sutton, G. M.</creator><creator>Wu, X.</creator><creator>Yu, G.</creator><creator>Goh, B. C.</creator><creator>Hebert, T.</creator><creator>Pelled, G.</creator><creator>Gazit, Z.</creator><creator>Gazit, D.</creator><creator>Butler, A. A.</creator><creator>Gimble, J. M.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110501</creationdate><title>Ovariectomy and genes encoding core circadian regulatory proteins in murine bone</title><author>Smith, B. J. ; Sutton, G. M. ; Wu, X. ; Yu, G. ; Goh, B. C. ; Hebert, T. ; Pelled, G. ; Gazit, Z. ; Gazit, D. ; Butler, A. A. ; Gimble, J. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-a63cc105e857358cfaa86d6a1ed83201f0922cc76d7fd873d52dae21f117f00f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Circadian Rhythm - genetics</topic><topic>Circadian Rhythm - physiology</topic><topic>Circadian Rhythm Signaling Peptides and Proteins - biosynthesis</topic><topic>Circadian Rhythm Signaling Peptides and Proteins - genetics</topic><topic>Disease Models, Animal</topic><topic>Diseases of the osteoarticular system</topic><topic>Endocrinology</topic><topic>Estrogens</topic><topic>Estrogens - deficiency</topic><topic>Estrogens - physiology</topic><topic>Female</topic><topic>Femur - metabolism</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation - physiology</topic><topic>Genes</topic><topic>Lumbar Vertebrae - metabolism</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Motor Activity - physiology</topic><topic>Orthopedics</topic><topic>Osteoporosis - genetics</topic><topic>Osteoporosis - metabolism</topic><topic>Osteoporosis - physiopathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Ovariectomy</topic><topic>Proteins</topic><topic>Rheumatology</topic><topic>RNA, Messenger - genetics</topic><topic>Rodents</topic><topic>Short Communication</topic><topic>Stem cells</topic><topic>Stress, Mechanical</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the genital tract and mammary gland</topic><topic>X-Ray Microtomography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, B. J.</creatorcontrib><creatorcontrib>Sutton, G. M.</creatorcontrib><creatorcontrib>Wu, X.</creatorcontrib><creatorcontrib>Yu, G.</creatorcontrib><creatorcontrib>Goh, B. C.</creatorcontrib><creatorcontrib>Hebert, T.</creatorcontrib><creatorcontrib>Pelled, G.</creatorcontrib><creatorcontrib>Gazit, Z.</creatorcontrib><creatorcontrib>Gazit, D.</creatorcontrib><creatorcontrib>Butler, A. A.</creatorcontrib><creatorcontrib>Gimble, J. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, B. J.</au><au>Sutton, G. M.</au><au>Wu, X.</au><au>Yu, G.</au><au>Goh, B. C.</au><au>Hebert, T.</au><au>Pelled, G.</au><au>Gazit, Z.</au><au>Gazit, D.</au><au>Butler, A. A.</au><au>Gimble, J. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovariectomy and genes encoding core circadian regulatory proteins in murine bone</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>22</volume><issue>5</issue><spage>1633</spage><epage>1639</epage><pages>1633-1639</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
This study investigated the influence of ovarian hormone deficiency on core circadian regulatory protein (CCRP) in the context of bone loss. Our data suggest that ovarian hormone deficiency disrupts diurnal rhythmicity and CCRP expression in bone. Further studies should determine if chronobiology provides a novel therapeutic target for osteoporosis intervention.
Introduction
CCRP synchronize metabolic activities and display an oscillatory expression profile in murine bone. In vitro studies using bone marrow mesenchymal stromal/stem cells have demonstrated that the CCRP is present and can be regulated within osteoblast progenitors. In vivo studies have shown that the CCRP regulates bone mass via leptin/neuroendocrine pathways. The current study used an ovariectomized murine model to test the hypothesis that ovarian hormone deficiency is associated with either an attenuation and/or temporal phase shift of the CCRP oscillatory expression in bone and that these changes are correlated with the onset of osteoporosis.
Methods
Sham-operated controls and ovariectomized female C57BL/6 mice were euthanized at 4-h intervals 2 weeks post-operatively.
Results
Ovariectomy attenuated the oscillatory expression of CCRP mRNAs in the femur and vertebra relative to the controls and reduced the wheel-running activity profile.
Conclusion
Ovarian hormone deficiency modulates the expression profile of the CCRP with potential impact on bone marrow mesenchymal stem cell lineage commitment.</abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>20593165</pmid><doi>10.1007/s00198-010-1325-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Osteoporosis international, 2011-05, Vol.22 (5), p.1633-1639 |
| issn | 0937-941X 1433-2965 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biological and medical sciences Bone marrow Circadian Rhythm - genetics Circadian Rhythm - physiology Circadian Rhythm Signaling Peptides and Proteins - biosynthesis Circadian Rhythm Signaling Peptides and Proteins - genetics Disease Models, Animal Diseases of the osteoarticular system Endocrinology Estrogens Estrogens - deficiency Estrogens - physiology Female Femur - metabolism Gene Expression Profiling - methods Gene Expression Regulation - physiology Genes Lumbar Vertebrae - metabolism Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL Motor Activity - physiology Orthopedics Osteoporosis - genetics Osteoporosis - metabolism Osteoporosis - physiopathology Osteoporosis. Osteomalacia. Paget disease Ovariectomy Proteins Rheumatology RNA, Messenger - genetics Rodents Short Communication Stem cells Stress, Mechanical Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland X-Ray Microtomography - methods |
| title | Ovariectomy and genes encoding core circadian regulatory proteins in murine bone |
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