Moderate-dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution

First-line therapy of severe aplastic anemia (SAA) with high-dose cyclophosphamide causes toxicity and increased short-term mortality. We investigated cyclophosphamide at a lower, more moderate dose in combination with aggressive supportive care to determine whether severe infections might be avoide...

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Veröffentlicht in:	Blood 2014-10, Vol.124 (18), p.2820-2823
Hauptverfasser:	Scheinberg, Phillip, Townsley, Danielle, Dumitriu, Bogdan, Scheinberg, Priscila, Weinstein, Barbara, Daphtary, Maithili, Rios, Olga, Wu, Colin O., Young, Neal S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Aplastic - drug therapy Brief Report Child Clinical Trials and Observations Clone Cells Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Cyclophosphamide - therapeutic use Dose-Response Relationship, Drug Humans Neutropenia - chemically induced Recurrence Survival Rate Voriconazole - therapeutic use
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