Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion

Aims Myopathy or neuropathy has been associated with lamivudine/telbivudine therapy in hepatitis B patients. We aim to describe the pathological changes of lamivudine/telbivudine-associated neuromyopathy. Methods We retrospectively recruited six patients who were diagnosed with nucleotide analogues-...

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Veröffentlicht in:	Journal of clinical pathology 2014-11, Vol.67 (11), p.999-1005
Hauptverfasser:	Xu, Hongliang, Wang, Zhaoxia, Zheng, Lemin, Zhang, Wei, Lv, He, Jin, Suqin, Yuan, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged, 80 and over Antiviral Agents - adverse effects Biopsy Deoxyribonucleic acid DNA DNA, Mitochondrial - metabolism Enzymes Female Hepatitis B - drug therapy Hepatitis B virus Hospitals Humans Infections Laboratories Lamivudine - adverse effects Male Microscopy, Electron Middle Aged Mitochondria Mitochondria, Muscle - drug effects Mitochondria, Muscle - metabolism Mitochondria, Muscle - ultrastructure Mitochondrial DNA Morphology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure Muscular Diseases - chemically induced Muscular Diseases - metabolism Muscular Diseases - pathology Original Patients Peripheral Nerves - drug effects Peripheral Nerves - metabolism Peripheral Nerves - ultrastructure Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - metabolism Peripheral Nervous System Diseases - pathology Predictive Value of Tests Real-Time Polymerase Chain Reaction Retrospective Studies Thymidine - adverse effects Thymidine - analogs & derivatives Young Adult
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