The contributory role of gut microbiota in cardiovascular disease
Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota-dependent form...
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| Veröffentlicht in: | The Journal of clinical investigation 2014-10, Vol.124 (10), p.4204-4211 |
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| container_title | The Journal of clinical investigation |
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| creator | Tang, W H Wilson Hazen, Stanley L |
| description | Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota-dependent formation of TMA and host hepatic flavin monooxygenase 3-dependent (FMO3-dependent) formation of TMA-N-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks. Collectively, these studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD. |
| doi_str_mv | 10.1172/JCI72331 |
| format | Article |
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A meta-organismal pathway was elucidated involving gut microbiota-dependent formation of TMA and host hepatic flavin monooxygenase 3-dependent (FMO3-dependent) formation of TMA-N-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks. Collectively, these studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI72331</identifier><identifier>PMID: 25271725</identifier><language>eng</language><publisher>United States: American Society for Clinical Investigation</publisher><subject>Animals ; Atherosclerosis ; Atherosclerosis - complications ; Atherosclerosis - microbiology ; Biomedical research ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - microbiology ; Carnitine - chemistry ; Choline - chemistry ; Deoxyribonucleic acid ; Diet ; Disease prevention ; DNA ; Female ; Food ; Health aspects ; Host-bacteria relationships ; Humans ; Influence ; Intestines - microbiology ; Male ; Medical research ; Medicine, Experimental ; Metabolic disorders ; Metabolites ; Methylamines - chemistry ; Microbiota ; Microbiota (Symbiotic organisms) ; Oxygenases - chemistry ; Pathogenesis ; Phosphatidylcholines - chemistry ; Physiology ; Plasma ; Review ; Risk factors ; Studies</subject><ispartof>The Journal of clinical investigation, 2014-10, Vol.124 (10), p.4204-4211</ispartof><rights>COPYRIGHT 2014 American Society for Clinical Investigation</rights><rights>Copyright American Society for Clinical Investigation Oct 2014</rights><rights>Copyright © 2014, American Society for Clinical Investigation 2014 American Society for Clinical Investigation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c742t-6cb4eaa5400f013e55984c166db50752c49899fc71c2bf29177aaa9b9f3a1e7d3</citedby><cites>FETCH-LOGICAL-c742t-6cb4eaa5400f013e55984c166db50752c49899fc71c2bf29177aaa9b9f3a1e7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215189/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215189/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25271725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, W H Wilson</creatorcontrib><creatorcontrib>Hazen, Stanley L</creatorcontrib><title>The contributory role of gut microbiota in cardiovascular disease</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota-dependent formation of TMA and host hepatic flavin monooxygenase 3-dependent (FMO3-dependent) formation of TMA-N-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks. Collectively, these studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD.</description><subject>Animals</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - microbiology</subject><subject>Biomedical research</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - microbiology</subject><subject>Carnitine - chemistry</subject><subject>Choline - chemistry</subject><subject>Deoxyribonucleic acid</subject><subject>Diet</subject><subject>Disease prevention</subject><subject>DNA</subject><subject>Female</subject><subject>Food</subject><subject>Health aspects</subject><subject>Host-bacteria relationships</subject><subject>Humans</subject><subject>Influence</subject><subject>Intestines - microbiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolic disorders</subject><subject>Metabolites</subject><subject>Methylamines - chemistry</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Oxygenases - chemistry</subject><subject>Pathogenesis</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Review</subject><subject>Risk factors</subject><subject>Studies</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkl1rFDEUhoModlsFf4EMCFIvpuZzktwIy-LHSqGg1duQyZyZTZmdtMlMsf_eLG5rR_ZCchFInvOek7wvQq8IPiNE0vdfV2tJGSNP0IIIoUpFmXqKFhhTUmrJ1BE6TukKY8K54M_RERVU5jqxQMvLDRQuDGP09TSGeFfE0EMR2qKbxmLrXQy1D6Mt_FA4Gxsfbm1yU29j0fgENsEL9Ky1fYKX-_0E_fj08XL1pTy_-LxeLc9LJzkdy8rVHKwVHOMWEwZCaMUdqaqmFlgK6rhWWrdOEkfrlmoipbVW17plloBs2An68Ef3eqq30DjIM9veXEe_tfHOBOvN_GbwG9OFW8MpEUTpLHC6F4jhZoI0mq1PDvreDhCmZEhFaYUFJzSjb_5Br8IUh_y8TBFGKMaq-kt1tgfjhzbkvm4napZMCa2VoCRT5QGqgwHykGGA1ufjGX92gM-rgWzHwYJ3s4Kdm_Br7OyUkll___b_7MXPOfv2EbsB24-bFPpp9GFIc3D_sTksKUVoH0wh2Ozyae7zmdHXj018AO8DyX4DHenbFA</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Tang, W H Wilson</creator><creator>Hazen, Stanley L</creator><general>American Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7T5</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201410</creationdate><title>The contributory role of gut microbiota in cardiovascular disease</title><author>Tang, W H Wilson ; Hazen, Stanley L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c742t-6cb4eaa5400f013e55984c166db50752c49899fc71c2bf29177aaa9b9f3a1e7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Animals Atherosclerosis Atherosclerosis - complications Atherosclerosis - microbiology Biomedical research Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - complications Cardiovascular Diseases - microbiology Carnitine - chemistry Choline - chemistry Deoxyribonucleic acid Diet Disease prevention DNA Female Food Health aspects Host-bacteria relationships Humans Influence Intestines - microbiology Male Medical research Medicine, Experimental Metabolic disorders Metabolites Methylamines - chemistry Microbiota Microbiota (Symbiotic organisms) Oxygenases - chemistry Pathogenesis Phosphatidylcholines - chemistry Physiology Plasma Review Risk factors Studies |
| title | The contributory role of gut microbiota in cardiovascular disease |
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