B2 Cells Suppress Experimental Abdominal Aortic Aneurysms

Recent reports of rupture in patients with abdominal aortic aneurysm (AAA) receiving B-cell depletion therapy highlight the importance of understanding the role of B cells (B1 and B2 subsets) in the development of AAA. We hypothesized that B2 cells aggravate experimental aneurysm formation. The IHC...

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Veröffentlicht in:	The American journal of pathology 2014-11, Vol.184 (11), p.3130-3141
Hauptverfasser:	Meher, Akshaya K, Johnston, William F, Lu, Guanyi, Pope, Nicolas H, Bhamidipati, Castigliano M, Harmon, Daniel B, Su, Gang, Zhao, Yunge, McNamara, Coleen A, Upchurch, Gilbert R, Ailawadi, Gorav
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Abdominal - metabolism Aortic Aneurysm, Abdominal - metabolism B-Lymphocytes - metabolism Disease Models, Animal Humans Mice Mice, Inbred C57BL Pathology Regular T-Lymphocytes, Regulatory - metabolism
Online-Zugang:	Volltext
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