CD4+ T cells enhance the unloaded shortening velocity of airway smooth muscle by altering the contractile protein expression

Key points Activated CD4+ T cells enhance the contractility of airway smooth muscle. In order to enhance contractility, contact between CD4+ T cells and smooth muscle is required. The enhanced contractility is correlated with increased levels of fast myosin isoform. Our data suggest that inflammator...

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Veröffentlicht in:	The Journal of physiology 2014-07, Vol.592 (14), p.2999-3012
Hauptverfasser:	Matusovsky, Oleg S., Nakada, Emily M., Kachmar, Linda, Fixman, Elizabeth D., Lauzon, Anne‐Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - physiology Coculture Techniques Contractile Proteins - physiology Male Molecular and Cellular Muscle Contraction - physiology Muscle, Smooth - physiology Myosin Light Chains - metabolism Myosin-Light-Chain Kinase - metabolism Ovalbumin - pharmacology Rats, Inbred BN Spleen - cytology Trachea - physiology
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