Glomerular autoimmune multicomponents of human lupus nephritis in vivo: α-enolase and annexin AI

Renal targets of autoimmunity in human lupus nephritis (LN) are unknown. We sought to identify autoantibodies and glomerular target antigens in renal biopsy samples from patients with LN and determine whether the same autoantibodies can be detected in circulation. Glomeruli were microdissected from...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2014-11, Vol.25 (11), p.2483-2498
Hauptverfasser:	Bruschi, Maurizio, Sinico, Renato Alberto, Moroni, Gabriella, Pratesi, Federico, Migliorini, Paola, Galetti, Maricla, Murtas, Corrado, Tincani, Angela, Madaio, Michael, Radice, Antonella, Franceschini, Franco, Trezzi, Barbara, Bianchi, Laura, Giallongo, Agata, Gatti, Rita, Tardanico, Regina, Scaloni, Andrea, D'Ambrosio, Chiara, Carnevali, Maria Luisa, Messa, Piergiorgio, Ravani, Pietro, Barbano, Giancarlo, Bianco, Beatrice, Bonanni, Alice, Scolari, Francesco, Martini, Alberto, Candiano, Giovanni, Allegri, Landino, Ghiggeri, Gian Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Annexin A1 - immunology Annexin A1 - isolation & purification Autoantibodies - blood Autoantibodies - immunology Basic Research Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Biomarkers, Tumor - isolation & purification Biopsy DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - isolation & purification Female Humans Immunoglobulin G - blood Immunoglobulin G - immunology Kidney Glomerulus - immunology Kidney Glomerulus - pathology Lupus Nephritis - immunology Lupus Nephritis - pathology Male Mice, Inbred BALB C Mice, Inbred MRL lpr Mice, SCID Middle Aged Phosphopyruvate Hydratase - genetics Phosphopyruvate Hydratase - immunology Phosphopyruvate Hydratase - isolation & purification Proteomics Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - immunology Tumor Suppressor Proteins - isolation & purification Young Adult
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