Hormones and diet, but not body weight, control hypothalamic microglial activity

The arcuate nucleus (ARC) of the hypothalamus plays a key role in sensing metabolic feedback and regulating energy homeostasis. Recent studies revealed activation of microglia in mice with high‐fat diet (HFD)‐induced obesity (DIO), suggesting a potential pathophysiological role for inflammatory proc...

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Veröffentlicht in:	Glia 2014-01, Vol.62 (1), p.17-25
Hauptverfasser:	Gao, Yuanqing, Ottaway, Nickki, Schriever, Sonja C., Legutko, Beata, García-Cáceres, Cristina, de la Fuente, Esther, Mergen, Clarita, Bour, Susanne, Thaler, Joshua P., Seeley, Randy J., Filosa, Jessica, Stern, Javier E., Perez-Tilve, Diego, Schwartz, Michael W., Tschöp, Matthias H., Yi, Chun-Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Body Weight - drug effects Body Weight - physiology Cytokinins - metabolism Diet, High-Fat - adverse effects Disease Models, Animal high calorie diet Hormones Hormones - pharmacology leptin Leptin - deficiency Leptin - pharmacology Mice Mice, Inbred C57BL Mice, Transgenic Microglia - drug effects Microglia - metabolism Obesity Obesity - chemically induced Obesity - physiopathology Peptides - pharmacology Receptor, Melanocortin, Type 4 - deficiency Receptors, Interleukin-8A - genetics Receptors, Interleukin-8A - metabolism Receptors, Leptin - deficiency Receptors, Leptin - genetics Rodents Signal Transduction - drug effects Supraoptic Nucleus - cytology Venoms - pharmacology
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