Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy
A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to ami...
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| Veröffentlicht in: | ACS nano 2014-10, Vol.8 (10), p.10621-10630 |
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| creator | Punjabi, Amol Wu, Xiang Tokatli-Apollon, Amira El-Rifai, Mahmoud Lee, Hyungseok Zhang, Yuanwei Wang, Chao Liu, Zhuang Chan, Emory M Duan, Chunying Han, Gang |
| description | A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP–PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors. It also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics. |
| doi_str_mv | 10.1021/nn505051d |
| format | Article |
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The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP–PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors. It also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.</description><subject>Amplification</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials</subject><subject>Biomedical materials</subject><subject>Drugs</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nanoparticles</subject><subject>NANOSCIENCE AND NANOTECHNOLOGY</subject><subject>Neoplasms - drug therapy</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>prodrug</subject><subject>Prodrugs - therapeutic use</subject><subject>red-emission</subject><subject>Surgical implants</subject><subject>Tumors</subject><subject>upconverting</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>N~.</sourceid><sourceid>EIF</sourceid><recordid>eNptkdFr1TAYxYsobk4f_AckCII-VJO0SdsXYV6mDoaK7IJvIU2-3makSU3SQd_2py-XOy8Kkod8IT_OdzinKF4S_J5gSj44x3A-RD8qTklX8RK3_Nfj48zISfEsxhuMWdM2_GlxQhntCKvr0-LufJqtGVbjdiiNgH6CLi8mE6PxDvkBbWfl3S2EtAe-SednmWdlIaLBB_TJeOWnWSbTW0Aba5xR0toVbSNo9CN4HZZdeen0ovbv0SevVycno9D1CEHO6_PiySBthBcP91mx_XxxvflaXn3_crk5vyplzVkqe9ZzRVQllWyHSumhJbStBko47pumwQS6RveMAai2rSqt6VDTutdD3zHgtK7Oio8H3XnpJ9AKXArSijmYSYZVeGnEvz_OjGLnb0VNCW26Lgu8Pgj4mIyIyiRQYw7HgUqCUNZUnGTo7cOW4H8vEJPIWSqwVjrwSxSk4RRnO4Rn9N0BVcHHGGA4eiFY7GsVx1oz--pv80fyT48ZeHMApIrixi_B5Sz_I3QPGkGtFw</recordid><startdate>20141028</startdate><enddate>20141028</enddate><creator>Punjabi, Amol</creator><creator>Wu, Xiang</creator><creator>Tokatli-Apollon, Amira</creator><creator>El-Rifai, Mahmoud</creator><creator>Lee, Hyungseok</creator><creator>Zhang, Yuanwei</creator><creator>Wang, Chao</creator><creator>Liu, Zhuang</creator><creator>Chan, Emory M</creator><creator>Duan, Chunying</creator><creator>Han, Gang</creator><general>American Chemical Society</general><scope>N~.</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>OIOZB</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20141028</creationdate><title>Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy</title><author>Punjabi, Amol ; Wu, Xiang ; Tokatli-Apollon, Amira ; El-Rifai, Mahmoud ; Lee, Hyungseok ; Zhang, Yuanwei ; Wang, Chao ; Liu, Zhuang ; Chan, Emory M ; Duan, Chunying ; Han, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a465t-b5b6c1c3aca8f3cdf81283f2160b77701e97db55eec8833dd2f424bdfb95e6243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amplification</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials</topic><topic>Biomedical materials</topic><topic>Drugs</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nanoparticles</topic><topic>NANOSCIENCE AND NANOTECHNOLOGY</topic><topic>Neoplasms - drug therapy</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>prodrug</topic><topic>Prodrugs - therapeutic use</topic><topic>red-emission</topic><topic>Surgical implants</topic><topic>Tumors</topic><topic>upconverting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Punjabi, Amol</creatorcontrib><creatorcontrib>Wu, Xiang</creatorcontrib><creatorcontrib>Tokatli-Apollon, Amira</creatorcontrib><creatorcontrib>El-Rifai, Mahmoud</creatorcontrib><creatorcontrib>Lee, Hyungseok</creatorcontrib><creatorcontrib>Zhang, Yuanwei</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Liu, Zhuang</creatorcontrib><creatorcontrib>Chan, Emory M</creatorcontrib><creatorcontrib>Duan, Chunying</creatorcontrib><creatorcontrib>Han, Gang</creatorcontrib><creatorcontrib>Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)</creatorcontrib><collection>American Chemical Society (ACS) Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Punjabi, Amol</au><au>Wu, Xiang</au><au>Tokatli-Apollon, Amira</au><au>El-Rifai, Mahmoud</au><au>Lee, Hyungseok</au><au>Zhang, Yuanwei</au><au>Wang, Chao</au><au>Liu, Zhuang</au><au>Chan, Emory M</au><au>Duan, Chunying</au><au>Han, Gang</au><aucorp>Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2014-10-28</date><risdate>2014</risdate><volume>8</volume><issue>10</issue><spage>10621</spage><epage>10630</epage><pages>10621-10630</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. 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| source | MEDLINE; ACS Publications |
| subjects | Amplification Biocompatibility Biocompatible Materials Biomedical materials Drugs HeLa Cells Humans Microscopy, Electron, Transmission Nanoparticles NANOSCIENCE AND NANOTECHNOLOGY Neoplasms - drug therapy Photochemotherapy Photodynamic therapy prodrug Prodrugs - therapeutic use red-emission Surgical implants Tumors upconverting |
| title | Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy |
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