CCL7 Is a Protective Factor Secreted by Mechanically Loaded Osteocytes

In a search for factors up-regulated by mechanical strain in osteocytes, we discovered that chemokine (C-C motif) ligand 7 (CCL7), a chemotactic myokine, was highly expressed in MLO-Y4 osteocyte-like cells. Although MLO-Y4 cells secrete potent chemotactic factors for osteoclast precursors, CCL7 was...

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Veröffentlicht in:	Journal of dental research 2014-11, Vol.93 (11), p.1108-1115
Hauptverfasser:	Kitase, Y., Lee, S., Gluhak-Heinrich, J., Johnson, M.L., Harris, S.E., Bonewald, L.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibodies - pharmacology Apoptosis Autocrine Communication - physiology Autocrine signalling beta Catenin - drug effects Biomechanical Phenomena Cell death Cell Death - drug effects Cell Line Cell Survival - physiology Chemokine CCL2 - metabolism Chemokine CCL7 - immunology Chemokine CCL7 - metabolism Chemokines Chemotactic factors Collagen Dexamethasone Dexamethasone - pharmacology Etoposide Etoposide - pharmacology Fluid flow Glucocorticoids Glucocorticoids - pharmacology Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - drug effects Homeostasis Indomethacin Indomethacin - pharmacology Mechanical loading Mechanical properties Mechanical stimuli Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 Osteoclasts - metabolism Osteocytes Osteoprogenitor cells Phosphorylation Protective Agents - metabolism Proteins Research Reports Rheology Shear stress Stress, Mechanical Tooth Movement Techniques - instrumentation Topoisomerase II Inhibitors - pharmacology Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α β-Catenin
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