RRHP: a tag-based approach for 5-hydroxymethylcytosine mapping at single-site resolution

Current methods for genomic mapping of 5-hydroxymethylcytosine (5hmC) have been limited by either costly sequencing depth, high DNA input, or lack of single-base resolution. We present an approach called Reduced Representation 5-Hydroxymethylcytosine Profiling (RRHP) to map 5hmC sites at single-base...

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Veröffentlicht in:	Genome Biology (Online Edition) 2014-09, Vol.15 (9), p.456-456, Article 456
Hauptverfasser:	Petterson, Adam, Chung, Tzu Hung, Tan, Darany, Sun, Xueguang, Jia, Xi-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives Cytosine - analogs & derivatives Cytosine - physiology DNA DNA Methylation Gene Library Genetic aspects Genomic libraries genomics High-Throughput Nucleotide Sequencing Humans Liver Neoplasms - genetics Method Molecular Sequence Annotation Sequence Analysis, DNA
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