E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Tumor suppressor p53 has a key role in maintaining genomic stability and preventing tumorigenesis through its regulation of cellular stress responses, including apoptosis, cell cycle arrest and senescence. To ensure its proper levels and functions in cells, p53 is tightly regulated mainly through po...

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Veröffentlicht in:	Cell death and differentiation 2014-11, Vol.21 (11), p.1792-1804
Hauptverfasser:	Liu, Ju, Zhang, C, Wang, X L, Ly, P, Belyi, V, Xu-Monette, Z Y, Young, K H, Hu, W, Feng, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 631/337 Animals Apoptosis Apoptosis - genetics Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell cycle Cell Cycle Analysis Cell death Cell Line, Tumor Cell Transformation, Neoplastic - genetics DNA Damage Genes Humans Life Sciences Mice Musculoskeletal system Oncology Original Paper Proteins Radiation Senescence Stem Cells Transcription Factors - genetics Tripartite Motif Proteins Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors Ubiquitin-Protein Ligases - genetics Ubiquitination
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