Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy
Nanomaterials with near-infrared (NIR) absorption have been widely studied in cancer detection and photothermal therapy (PTT), while it remains a great challenge in targeting tumor efficiently with minimal side effects. Herein we report a novel multifunctional phage-mimetic nanostructure, which was...
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| description | Nanomaterials with near-infrared (NIR) absorption have been widely studied in cancer detection and photothermal therapy (PTT), while it remains a great challenge in targeting tumor efficiently with minimal side effects. Herein we report a novel multifunctional phage-mimetic nanostructure, which was prepared by layer-by-layer self-assembly of Au@Ag heterogenous nanorods (NRs) with rhodamine 6G and specific pVIII fusion proteins. Au@Ag NRs, first being applied for PTT, exhibited excellent stability, cost-effectivity, biocompatibility and tunable NIR absorption. The fusion proteins were isolated from phage DDAGNRQP specifically selected from f8/8 landscape phage library against colorectal cancer cells in a high-throughput way. Considering the definite charge distribution and low molecular weight, phage fusion proteins were assembled on the negatively charged NR core by electrostatic interactions, exposing the N-terminus fused with DDAGNRQP peptide on the surface. The fluorescent images showed that assembled phage fusion proteins can direct the nanostructure into cancer cells. The nanostructure was more efficient than gold nanorods and silver nanotriangle-based photothermal agents and was capable of specifically ablating SW620 cells after 10 min illumination with an 808 nm laser in the light intensity of 4 W/cm
2
. The prepared nanostructure would become an ideal reagent for simutaneously targeted optical imaging and PTT of tumor. |
| doi_str_mv | 10.1038/srep06808 |
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2
. The prepared nanostructure would become an ideal reagent for simutaneously targeted optical imaging and PTT of tumor.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep06808</identifier><identifier>PMID: 25348392</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/432 ; 631/61/2049 ; 639/925/352/2733 ; 639/925/352/2734 ; Absorption ; Biocompatibility ; Biomimetics ; Cancer ; Capsid Proteins - chemistry ; Capsid Proteins - therapeutic use ; Cell Line, Tumor ; Colorectal carcinoma ; Colorectal Neoplasms - therapy ; Colorectal Neoplasms - ultrastructure ; Colorectal Neoplasms - virology ; Electrostatic properties ; Gold - chemistry ; Humanities and Social Sciences ; Humans ; I.R. radiation ; Illumination ; Light intensity ; Molecular weight ; multidisciplinary ; N-Terminus ; Nanostructures - chemistry ; Nanostructures - therapeutic use ; Nanotechnology ; Nanotubes - chemistry ; Phages ; Phototherapy ; Proteins ; Rhodamine 6G ; Rhodamines - chemistry ; Rhodamines - therapeutic use ; Science ; Self-assembly ; Side effects ; Silver ; Silver - chemistry ; Spectroscopy, Near-Infrared</subject><ispartof>Scientific reports, 2014-10, Vol.4 (1), p.6808, Article 6808</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Oct 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f2b6b92fc3659cbe8d4e3a428bda1e08deea5dc92d2bfd42881c86e1e1b9bc283</citedby><cites>FETCH-LOGICAL-c438t-f2b6b92fc3659cbe8d4e3a428bda1e08deea5dc92d2bfd42881c86e1e1b9bc283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25348392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Liu, Pei</creatorcontrib><creatorcontrib>Sun, Lin</creatorcontrib><creatorcontrib>Li, Cuncheng</creatorcontrib><creatorcontrib>Petrenko, Valery A.</creatorcontrib><creatorcontrib>Liu, Aihua</creatorcontrib><title>Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Nanomaterials with near-infrared (NIR) absorption have been widely studied in cancer detection and photothermal therapy (PTT), while it remains a great challenge in targeting tumor efficiently with minimal side effects. Herein we report a novel multifunctional phage-mimetic nanostructure, which was prepared by layer-by-layer self-assembly of Au@Ag heterogenous nanorods (NRs) with rhodamine 6G and specific pVIII fusion proteins. Au@Ag NRs, first being applied for PTT, exhibited excellent stability, cost-effectivity, biocompatibility and tunable NIR absorption. The fusion proteins were isolated from phage DDAGNRQP specifically selected from f8/8 landscape phage library against colorectal cancer cells in a high-throughput way. Considering the definite charge distribution and low molecular weight, phage fusion proteins were assembled on the negatively charged NR core by electrostatic interactions, exposing the N-terminus fused with DDAGNRQP peptide on the surface. The fluorescent images showed that assembled phage fusion proteins can direct the nanostructure into cancer cells. The nanostructure was more efficient than gold nanorods and silver nanotriangle-based photothermal agents and was capable of specifically ablating SW620 cells after 10 min illumination with an 808 nm laser in the light intensity of 4 W/cm
2
. The prepared nanostructure would become an ideal reagent for simutaneously targeted optical imaging and PTT of tumor.</description><subject>631/326/432</subject><subject>631/61/2049</subject><subject>639/925/352/2733</subject><subject>639/925/352/2734</subject><subject>Absorption</subject><subject>Biocompatibility</subject><subject>Biomimetics</subject><subject>Cancer</subject><subject>Capsid Proteins - chemistry</subject><subject>Capsid Proteins - therapeutic use</subject><subject>Cell Line, Tumor</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Colorectal Neoplasms - ultrastructure</subject><subject>Colorectal Neoplasms - virology</subject><subject>Electrostatic properties</subject><subject>Gold - chemistry</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>I.R. radiation</subject><subject>Illumination</subject><subject>Light intensity</subject><subject>Molecular weight</subject><subject>multidisciplinary</subject><subject>N-Terminus</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - therapeutic use</subject><subject>Nanotechnology</subject><subject>Nanotubes - chemistry</subject><subject>Phages</subject><subject>Phototherapy</subject><subject>Proteins</subject><subject>Rhodamine 6G</subject><subject>Rhodamines - chemistry</subject><subject>Rhodamines - therapeutic use</subject><subject>Science</subject><subject>Self-assembly</subject><subject>Side effects</subject><subject>Silver</subject><subject>Silver - chemistry</subject><subject>Spectroscopy, Near-Infrared</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkclqHDEQhoWJiY3tQ17ACHKKoWNJvaC-hIwdb2BiQyZnoaW6p0231NES8OvkSaPxOMOY6FKqqq_-KvgR-kDJZ0pKfh48zKThhO-hQ0aqumAlY-92_gfoJIQnkl_N2oq279EBq8uKly07RH8uBldMwwRx0Pi7tC5En3RMHvAPGLtChgCTGsHgzrsJL9LXRY9vIYJ3PVhwKbxMeWcCltbgx5XsAV-nMDiLH72LMNiAO-fxUvo-zxm8TFNOH-a8UY74W67puKY34y66uAI_5dYyRzk_H6P9To4BTl7jEfp5fbW8vC3uH27uLhf3ha5KHouOqUa1rNNlU7daATcVlLJiXBlJgXADIGujW2aY6kyuc6p5AxSoapVmvDxCXza6c1ITGA02ejmK2Q-T9M_CyUG87dhhJXr3W1SMEt6sBT6-Cnj3K0GI4sklb_PNgvKW07qpOM3Upw2lvQvZvG67gRKxdlRsHc3s6e5JW_Kffxk42wAht2wPfmflf2p_ASQ1r9Q</recordid><startdate>20141028</startdate><enddate>20141028</enddate><creator>Wang, Fei</creator><creator>Liu, Pei</creator><creator>Sun, Lin</creator><creator>Li, Cuncheng</creator><creator>Petrenko, Valery A.</creator><creator>Liu, Aihua</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20141028</creationdate><title>Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy</title><author>Wang, Fei ; Liu, Pei ; Sun, Lin ; Li, Cuncheng ; Petrenko, Valery A. ; Liu, Aihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f2b6b92fc3659cbe8d4e3a428bda1e08deea5dc92d2bfd42881c86e1e1b9bc283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/326/432</topic><topic>631/61/2049</topic><topic>639/925/352/2733</topic><topic>639/925/352/2734</topic><topic>Absorption</topic><topic>Biocompatibility</topic><topic>Biomimetics</topic><topic>Cancer</topic><topic>Capsid Proteins - chemistry</topic><topic>Capsid Proteins - therapeutic use</topic><topic>Cell Line, Tumor</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - therapy</topic><topic>Colorectal Neoplasms - ultrastructure</topic><topic>Colorectal Neoplasms - virology</topic><topic>Electrostatic properties</topic><topic>Gold - chemistry</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>I.R. radiation</topic><topic>Illumination</topic><topic>Light intensity</topic><topic>Molecular weight</topic><topic>multidisciplinary</topic><topic>N-Terminus</topic><topic>Nanostructures - chemistry</topic><topic>Nanostructures - therapeutic use</topic><topic>Nanotechnology</topic><topic>Nanotubes - chemistry</topic><topic>Phages</topic><topic>Phototherapy</topic><topic>Proteins</topic><topic>Rhodamine 6G</topic><topic>Rhodamines - chemistry</topic><topic>Rhodamines - therapeutic use</topic><topic>Science</topic><topic>Self-assembly</topic><topic>Side effects</topic><topic>Silver</topic><topic>Silver - chemistry</topic><topic>Spectroscopy, Near-Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Liu, Pei</creatorcontrib><creatorcontrib>Sun, Lin</creatorcontrib><creatorcontrib>Li, Cuncheng</creatorcontrib><creatorcontrib>Petrenko, Valery A.</creatorcontrib><creatorcontrib>Liu, Aihua</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Fei</au><au>Liu, Pei</au><au>Sun, Lin</au><au>Li, Cuncheng</au><au>Petrenko, Valery A.</au><au>Liu, Aihua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-10-28</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>6808</spage><pages>6808-</pages><artnum>6808</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Nanomaterials with near-infrared (NIR) absorption have been widely studied in cancer detection and photothermal therapy (PTT), while it remains a great challenge in targeting tumor efficiently with minimal side effects. Herein we report a novel multifunctional phage-mimetic nanostructure, which was prepared by layer-by-layer self-assembly of Au@Ag heterogenous nanorods (NRs) with rhodamine 6G and specific pVIII fusion proteins. Au@Ag NRs, first being applied for PTT, exhibited excellent stability, cost-effectivity, biocompatibility and tunable NIR absorption. The fusion proteins were isolated from phage DDAGNRQP specifically selected from f8/8 landscape phage library against colorectal cancer cells in a high-throughput way. Considering the definite charge distribution and low molecular weight, phage fusion proteins were assembled on the negatively charged NR core by electrostatic interactions, exposing the N-terminus fused with DDAGNRQP peptide on the surface. The fluorescent images showed that assembled phage fusion proteins can direct the nanostructure into cancer cells. The nanostructure was more efficient than gold nanorods and silver nanotriangle-based photothermal agents and was capable of specifically ablating SW620 cells after 10 min illumination with an 808 nm laser in the light intensity of 4 W/cm
2
. The prepared nanostructure would become an ideal reagent for simutaneously targeted optical imaging and PTT of tumor.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25348392</pmid><doi>10.1038/srep06808</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/326/432 631/61/2049 639/925/352/2733 639/925/352/2734 Absorption Biocompatibility Biomimetics Cancer Capsid Proteins - chemistry Capsid Proteins - therapeutic use Cell Line, Tumor Colorectal carcinoma Colorectal Neoplasms - therapy Colorectal Neoplasms - ultrastructure Colorectal Neoplasms - virology Electrostatic properties Gold - chemistry Humanities and Social Sciences Humans I.R. radiation Illumination Light intensity Molecular weight multidisciplinary N-Terminus Nanostructures - chemistry Nanostructures - therapeutic use Nanotechnology Nanotubes - chemistry Phages Phototherapy Proteins Rhodamine 6G Rhodamines - chemistry Rhodamines - therapeutic use Science Self-assembly Side effects Silver Silver - chemistry Spectroscopy, Near-Infrared |
| title | Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy |
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