heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

Barrier characteristics of brain endothelial cells forming the blood–brain barrier (BBB) are tightly regulated by cellular and acellular components of the neurovascular unit. During embryogenesis, the accumulation of the heparan sulfate proteoglycan agrin in the basement membranes ensheathing brain...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell and tissue research 2014-11, Vol.358 (2), p.465-479
Hauptverfasser:	Steiner, Esther, Enzmann, Gaby U, Lyck, Ruth, Lin, Shuo, Rüegg, Markus A, Kröger, Stephan, Engelhardt, Britta
Format:	Artikel
Sprache:	eng
Schlagworte:	adherens junctions Adherens Junctions - metabolism Agrin - metabolism Analysis Animals Antigens, CD - metabolism beta Catenin - metabolism Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - cytology Blood-Brain Barrier - metabolism brain Cadherins - metabolism Cell Proliferation Cellular biology Chickens embryogenesis Embryonic development endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium HEK293 Cells heparan sulfate Heparan Sulfate Proteoglycans - metabolism Human Genetics Humans Membranes Mice Microvessels - cytology Microvessels - metabolism Molecular Medicine neoplasms occludins Permeability Protein expression Protein Stability Protein Transport Proteins proteoglycans Proteomics Regular Regular Article Rodents Signal transduction Staining and Labeling Sulfates Zonula Occludens-1 Protein - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!