Engineering a memory with LTD and LTP

A rodent study using optogenetics to induce long-term potentiation and long-term depression provides a causal link between synaptic plasticity and memory. Memories made and unmade It has long been thought that the neural mechanisms underlying memories involve synaptic plasticity such as long-term po...

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Veröffentlicht in:	Nature (London) 2014-07, Vol.511 (7509), p.348-352
Hauptverfasser:	Nabavi, Sadegh, Fox, Rocky, Proulx, Christophe D., Lin, John Y., Tsien, Roger Y., Malinow, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	45/44 631/378/1595 631/378/2591/2592 631/378/2591/2593 9/30 9/74 Amygdala - physiology Animals Bioengineering Conditioning, Psychological - physiology Electric Stimulation Electrophysiology Fear - physiology Fear - psychology Humanities and Social Sciences Inactivation letter Long-term potentiation Long-Term Potentiation - physiology Long-Term Synaptic Depression - physiology Male Memory Memory - physiology multidisciplinary Neurological research Neurology Neurophysiology Neuroplasticity Optogenetics Rats Rats, Sprague-Dawley Rodents Science Synapses - physiology Synaptic Transmission
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