Parallel Evolution of Tetrodotoxin Resistance in Three Voltage-Gated Sodium Channel Genes in the Garter Snake Thamnophis sirtalis

Members of a gene family expressed in a single species often experience common selection pressures. Consequently, the molecular basis of complex adaptations may be expected to involve parallel evolutionary changes in multiple paralogs. Here, we use bacterial artificial chromosome library scans to in...

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Veröffentlicht in:	Molecular biology and evolution 2014-11, Vol.31 (11), p.2836-2846
Hauptverfasser:	McGlothlin, Joel W., Chuckalovcak, John P., Janes, Daniel E., Edwards, Scott V., Feldman, Chris R., Brodie, Edmund D., Pfrender, Michael E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Amino Acid Sequence Amino acids Animals Biological Evolution Central nervous system Chromosomes, Artificial, Bacterial Colubridae - genetics DNA Transposable Elements Drug Resistance - genetics Evolution Exons Fast Track Gene expression Gene Library Genes Introns Microsatellite Repeats Molecular Sequence Data Nervous system Predatory Behavior Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Salamandridae - physiology Sequence Alignment Snakes Sodium Sodium Channel Blockers - metabolism Sodium Channel Blockers - toxicity Tetrodotoxin - biosynthesis Tetrodotoxin - toxicity Toxins Voltage-Gated Sodium Channels - chemistry Voltage-Gated Sodium Channels - genetics Voltage-Gated Sodium Channels - metabolism
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