Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

Mesenchymal stem cells (MSCs) possess unique paracrine and immunosuppressive properties, which make them useful candidates for cellular therapy. Here, we address how cellular senescence influences the therapeutic potential of human MSCs (hMSCs). Senescence was induced in bone marrow‐derived hMSC cul...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2014-07, Vol.32 (7), p.1865-1877
Hauptverfasser:	Carlos Sepúlveda, Juan, Tomé, María, Eugenia Fernández, María, Delgado, Mario, Campisi, Judith, Bernad, Antonio, González, Manuel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cell Movement Cell Proliferation Cells, Cultured Cellular Senescence Cellular therapy Endotoxemia - immunology Endotoxemia - therapy Gene expression Humans Immunomodulation Immunotherapy Lipopolysaccharides - pharmacology Lymphocytes - immunology Male Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - physiology Mice, Inbred BALB C Plectin - genetics Plectin - metabolism Senescence Stem cells Transcription Factor AP-1 - metabolism Transcriptome TRPC Cation Channels - genetics TRPC Cation Channels - metabolism
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