Differential methylation of the micro‐RNA 7b gene targets postnatal maturation of murine neuronal Mecp2 gene expression

ABSTRACT DNA methylation and microRNAs (miRNAs) play crucial roles in maturation of postnatal mouse neurons. Aberrant DNA methylation and/or altered miRNA expression cause postnatal neurodevelopmental disorders. In general, DNA methylation in the 5′‐flanking region suppresses gene expression through...

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Veröffentlicht in:	Developmental neurobiology (Hoboken, N.J.) N.J.), 2014-04, Vol.74 (4), p.407-425
Hauptverfasser:	Chen, Yongjun, Shin, Bo‐Chul, Thamotharan, Shanthie, Devaskar, Sherin U.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 5' Flanking Region Animals Base Sequence Brain - growth & development Brain - physiology Cell Line Cells, Cultured CpG Islands DNA methylation epigenetic regulation Gene Expression Hippocampus - growth & development Hippocampus - physiology histone deacetylase Methyl-CpG-Binding Protein 2 - metabolism Methylation Mice Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism miRNA biogenesis Molecular Sequence Data neurodevelopment Neurons - physiology transcriptional control
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