Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin‐treated, apolipoprotein E‐deficient mice

The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2. To determine the contribution of these dicarbonyls to t...

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Veröffentlicht in:	Physiological reports 2014-06, Vol.2 (6), p.e12043-n/a
Hauptverfasser:	Geoffrion, Michèle, Du, Xueliang, Irshad, Zehra, Vanderhyden, Barbara C., Courville, Kerri, Sui, Guangzhi, D'Agati, Vivette D., Ott‐Braschi, Sylvie, Rabbani, Naila, Thornalley, Paul J., Brownlee, Michael, Milne, Ross W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Age Aorta ApoE‐deficient mice Apolipoprotein E Apolipoproteins Arteriosclerosis Atherosclerosis Cholesterol Diabetes Diabetes mellitus Diabetic retinopathy Etiology Gene expression Glycosylation glyoxalase Hyperglycemia Kidney diseases Ligands Metabolism nephropathy Original Research Oxidative stress Pathology Physiology Proteins Pyruvaldehyde Renal function Smooth muscle Streptozocin Transgenic animals Triglycerides
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