The role of SUMO-1 in cardiac oxidative stress and hypertrophy

Small ubiquitin-like modifier type 1 (SUMO-1) has been shown to play a critical role in the dysfunction of the cardiac isoform of sarcoplasmic reticulum calcium ATPase (SERCA2a) pump in the setting of heart failure. In cardiac hypertrophy, the role of SUMO-1 has not been defined and our study's...

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Veröffentlicht in:	Antioxidants & redox signaling 2014-11, Vol.21 (14), p.1986-2001
Hauptverfasser:	Lee, Ahyoung, Jeong, Dongtak, Mitsuyama, Shinichi, Oh, Jae Gyun, Liang, Lifan, Ikeda, Yoshiyuki, Sadoshima, Junichi, Hajjar, Roger J, Kho, Changwon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - pathology Cells, Cultured Forum Original Research Communications Gene Targeting Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Mice Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxidative Stress Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism SUMO-1 Protein - genetics SUMO-1 Protein - metabolism
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