Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures

Leucin-rich, glioma inactivated 1 (LGI1) is a secreted protein linked to human seizures of both genetic and autoimmune aetiology. Mutations in the LGI1 gene are responsible for autosomal dominant temporal lobe epilepsy with auditory features, whereas LGI1 autoantibodies are involved in limbic enceph...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2014-11, Vol.137 (Pt 11), p.2984-2996
Hauptverfasser:	BOILLOT, Morgane, HUNEAU, Clément, MARTIN, Benoit, LEGUERN, Eric, ANDERSON, Matthew P, BAULAC, Stéphanie, MARSAN, Elise, LEHONGRE, Katia, NAVARRO, Vincent, ISHIDA, Saeko, DUFRESNOIS, Béatrice, OZKAYNAK, Ekim, GARRIGUE, Jérôme, MILES, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Biological and medical sciences Brain - metabolism Brain - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electroencephalography Embryo, Mammalian - metabolism GABAergic Neurons - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Human health and pathology Interneurons - metabolism Life Sciences Medical sciences Mice Mice, Knockout Nervous system (semeiology, syndromes) Neurobiology Neurology Neurons - metabolism Neurons and Cognition Original Proteins - genetics Proteins - physiology Pyramidal Cells - metabolism Seizures - etiology Seizures - genetics
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