Pyk2 promotes tumor progression in multiple myeloma

Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor development. However, its role in modulating multiple myeloma (MM) biology and disease progression remains unexplored. We first demonstrated that patients with MM present with...

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Veröffentlicht in:	Blood 2014-10, Vol.124 (17), p.2675-2686
Hauptverfasser:	Zhang, Yu, Moschetta, Michele, Huynh, Daisy, Tai, Yu-Tzu, Zhang, Yong, Zhang, Wenjing, Mishima, Yuji, Ring, Jennifer E., Tam, Winnie F., Xu, Qunli, Maiso, Patricia, Reagan, Michaela, Sahin, Ilyas, Sacco, Antonio, Manier, Salomon, Aljawai, Yosra, Glavey, Siobhan, Munshi, Nikhil C., Anderson, Kenneth C., Pachter, Jonathan, Roccaro, Aldo M., Ghobrial, Irene M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Animals beta Catenin - metabolism Cell Adhesion - drug effects Cell Adhesion - genetics Cell Cycle - drug effects Cell Cycle - genetics Cell Line, Tumor Cell Proliferation - drug effects Cells, Cultured Disease Progression Female Focal Adhesion Kinase 2 - antagonists & inhibitors Focal Adhesion Kinase 2 - genetics Focal Adhesion Kinase 2 - metabolism Gene Expression Regulation, Enzymologic - drug effects Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Humans Immunoblotting Luminescent Measurements Lymphoid Neoplasia Mice, SCID Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - prevention & control Protein Kinase Inhibitors - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA Interference Survival Analysis Tumor Burden - drug effects Tumor Burden - genetics Wnt Signaling Pathway - drug effects Xenograft Model Antitumor Assays
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