Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus

Staphylococcus aureus is a rapidly growing health threat in the U.S., with resistance to several commonly prescribed treatments. A high-throughput screen identified the antihistamine terfenadine to possess, previously unreported, antimicrobial activity against S. aureus and other Gram-positive bacte...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-10, Vol.57 (20), p.8540-8562
Hauptverfasser:	Perlmutter, Jessamyn I, Forbes, Lauren T, Krysan, Damian J, Ebsworth-Mojica, Katherine, Colquhoun, Jennifer M, Wang, Jenna L, Dunman, Paul M, Flaherty, Daniel P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Chemistry Techniques, Synthetic DNA Gyrase - chemistry DNA Gyrase - metabolism DNA Topoisomerase IV - antagonists & inhibitors Dose-Response Relationship, Drug ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - antagonists & inhibitors Histamine H1 Antagonists, Non-Sedating - chemistry Humans Inhibitory Concentration 50 Microbial Sensitivity Tests Models, Molecular Mycobacterium tuberculosis Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Structure-Activity Relationship Terfenadine - analogs & derivatives Terfenadine - chemistry Topoisomerase II Inhibitors - chemistry Topoisomerase II Inhibitors - pharmacology
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