Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells

Tumor heterogeneity is in part determined by the existence of cancer stem cells (CSCs) and more differentiated tumor cells. CSCs are considered to be the tumorigenic root of cancers and suggested to be chemotherapy resistant. Here we exploited an assay that allowed us to measure chemotherapy-induced...

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Veröffentlicht in:	Cell death and differentiation 2014-07, Vol.21 (7), p.1170-1177
Hauptverfasser:	Colak, S, Zimberlin, C D, Fessler, E, Hogdal, L, Prasetyanti, P R, Grandela, C M, Letai, A, Medema, J P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2326 631/67/1059/99 631/67/1504/1885/1393 631/80/82/23 Antineoplastic Agents - pharmacology Apoptosis bcl-X Protein - antagonists & inhibitors Biochemistry Biomedical and Life Sciences Cancer therapies Cell Biology Cell Cycle Analysis Cell death Cell Survival Chemotherapy Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Colorectal cancer Drug Resistance, Neoplasm Humans Leukemia Life Sciences Lymphoma Mitochondria - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - physiology Oncology Original Paper Proteins Stem Cells Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
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