Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained i...
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| Veröffentlicht in: | International journal of nanomedicine 2014-01, Vol.9, p.4697-4707 |
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| container_title | International journal of nanomedicine |
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| creator | Li, Bo Zhang, Xiao-Yong Yang, Jian-Zhong Zhang, Yu-Jie Li, Wen-Xin Fan, Chun-Hai Huang, Qing |
| description | In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis. |
| doi_str_mv | 10.2147/ijn.s66591 |
| format | Article |
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The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis.</description><identifier>ISSN: 1178-2013</identifier><identifier>ISSN: 1176-9114</identifier><identifier>EISSN: 1178-2013</identifier><identifier>DOI: 10.2147/ijn.s66591</identifier><identifier>PMID: 25356071</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Animals ; Applied physics ; Biocompatibility ; biodistribution ; Biomedical materials ; Body Weight - drug effects ; Cancer therapies ; Coated Materials, Biocompatible - chemistry ; Coated Materials, Biocompatible - pharmacokinetics ; Drug dosages ; Fourier transforms ; Graphene ; graphene oxide ; Graphite - administration & dosage ; Graphite - chemistry ; Graphite - pharmacokinetics ; Injections, Intravenous ; Liver - drug effects ; Liver - pathology ; Lung - drug effects ; Lung - pathology ; Male ; Mice ; Microscopy ; Nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Nanoparticles - toxicity ; Original Research ; Physiological aspects ; Polyethylene glycol ; Polyethylene Glycols - administration & dosage ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacokinetics ; Polyethylene Glycols - pharmacology ; Properties ; Tissue Distribution - drug effects ; toxicity ; Toxicology</subject><ispartof>International journal of nanomedicine, 2014-01, Vol.9, p.4697-4707</ispartof><rights>COPYRIGHT 2014 Dove Medical Press Limited</rights><rights>2014. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-9ac36bb73e37049c0d163ed2b117e8c4366a754d3a003125fd998597a991c393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207078/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207078/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25356071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Zhang, Xiao-Yong</creatorcontrib><creatorcontrib>Yang, Jian-Zhong</creatorcontrib><creatorcontrib>Zhang, Yu-Jie</creatorcontrib><creatorcontrib>Li, Wen-Xin</creatorcontrib><creatorcontrib>Fan, Chun-Hai</creatorcontrib><creatorcontrib>Huang, Qing</creatorcontrib><title>Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection</title><title>International journal of nanomedicine</title><addtitle>Int J Nanomedicine</addtitle><description>In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis.</description><subject>Animals</subject><subject>Applied physics</subject><subject>Biocompatibility</subject><subject>biodistribution</subject><subject>Biomedical materials</subject><subject>Body Weight - drug effects</subject><subject>Cancer therapies</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coated Materials, Biocompatible - pharmacokinetics</subject><subject>Drug dosages</subject><subject>Fourier transforms</subject><subject>Graphene</subject><subject>graphene oxide</subject><subject>Graphite - administration & dosage</subject><subject>Graphite - chemistry</subject><subject>Graphite - pharmacokinetics</subject><subject>Injections, Intravenous</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Mice</subject><subject>Microscopy</subject><subject>Nanoparticles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - toxicity</subject><subject>Original Research</subject><subject>Physiological aspects</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - administration & dosage</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacokinetics</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Properties</subject><subject>Tissue Distribution - drug effects</subject><subject>toxicity</subject><subject>Toxicology</subject><issn>1178-2013</issn><issn>1176-9114</issn><issn>1178-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUk1v1DAQjRCIlsKFH4AicUFIu_gjseMLUlVRWFTBgd4tx5nseuXYi-2syD_gZ9dhl7aLkA_2jN97M36eoniN0ZLgin8wW7eMjNUCPynOMebNgiBMnz46nxUvYtwiVPOGiefFGalpzRDH58XvlevtCE5D6fty5-0EaTNZcFCu7aS9LbVXybh16V3ZGt-ZmIJpx2RyrFxXJv_LaJOmme6U81Erm7lB7TazSL7toDSuHEwuofoEIUcpqD04P8Z83oKexV4Wz3plI7w67hfF7fWn26svi5vvn1dXlzcLzXCTFkJpytqWU6AcVUKjDjMKHWnzW6HRFWVM8brqqEKIYlL3nRBNLbgSAmsq6EXx8SC7G9sBOg1zL1bughlUmKRXRp7eOLORa7-XFUEc8SYLoINA5_ewCxDjCfkhq_0gcbYbZ8q7Y83gf44QkxxM1GCtcpA9kJgRLhjHVZWhb_-Bbv0YXDZEEkKF4II39QNqnb2WxvU-t6pnUXlZIUzwsdPlf1B5dZA_wzvoTc6fEN4fCDr4GAP09y_DSM6TJldfv8kffyYtg988NvIe-ne06B2xzNFm</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Li, Bo</creator><creator>Zhang, Xiao-Yong</creator><creator>Yang, Jian-Zhong</creator><creator>Zhang, Yu-Jie</creator><creator>Li, Wen-Xin</creator><creator>Fan, Chun-Hai</creator><creator>Huang, Qing</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Press</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection</title><author>Li, Bo ; Zhang, Xiao-Yong ; Yang, Jian-Zhong ; Zhang, Yu-Jie ; Li, Wen-Xin ; Fan, Chun-Hai ; Huang, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-9ac36bb73e37049c0d163ed2b117e8c4366a754d3a003125fd998597a991c393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Applied physics</topic><topic>Biocompatibility</topic><topic>biodistribution</topic><topic>Biomedical materials</topic><topic>Body Weight - drug effects</topic><topic>Cancer therapies</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coated Materials, Biocompatible - pharmacokinetics</topic><topic>Drug dosages</topic><topic>Fourier transforms</topic><topic>Graphene</topic><topic>graphene oxide</topic><topic>Graphite - administration & dosage</topic><topic>Graphite - chemistry</topic><topic>Graphite - pharmacokinetics</topic><topic>Injections, Intravenous</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Mice</topic><topic>Microscopy</topic><topic>Nanoparticles</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - toxicity</topic><topic>Original Research</topic><topic>Physiological aspects</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols - administration & dosage</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - pharmacokinetics</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Properties</topic><topic>Tissue Distribution - drug effects</topic><topic>toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Zhang, Xiao-Yong</creatorcontrib><creatorcontrib>Yang, Jian-Zhong</creatorcontrib><creatorcontrib>Zhang, Yu-Jie</creatorcontrib><creatorcontrib>Li, Wen-Xin</creatorcontrib><creatorcontrib>Fan, Chun-Hai</creatorcontrib><creatorcontrib>Huang, Qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of nanomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Bo</au><au>Zhang, Xiao-Yong</au><au>Yang, Jian-Zhong</au><au>Zhang, Yu-Jie</au><au>Li, Wen-Xin</au><au>Fan, Chun-Hai</au><au>Huang, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection</atitle><jtitle>International journal of nanomedicine</jtitle><addtitle>Int J Nanomedicine</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>9</volume><spage>4697</spage><epage>4707</epage><pages>4697-4707</pages><issn>1178-2013</issn><issn>1176-9114</issn><eissn>1178-2013</eissn><abstract>In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>25356071</pmid><doi>10.2147/ijn.s66591</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; MEDLINE; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Applied physics Biocompatibility biodistribution Biomedical materials Body Weight - drug effects Cancer therapies Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacokinetics Drug dosages Fourier transforms Graphene graphene oxide Graphite - administration & dosage Graphite - chemistry Graphite - pharmacokinetics Injections, Intravenous Liver - drug effects Liver - pathology Lung - drug effects Lung - pathology Male Mice Microscopy Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - toxicity Original Research Physiological aspects Polyethylene glycol Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - pharmacology Properties Tissue Distribution - drug effects toxicity Toxicology |
| title | Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection |
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