Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

Common pharmacological treatments of neuropathic and chronic inflammatory pain conditions generally lack efficacy and/or are associated with significant untoward side effects. However, recent preclinical data indicate that combined inhibition of cyclooxygenase (COX) and fatty acid amide hydrolase (F...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2014-09, Vol.124, p.405-411
Hauptverfasser:	Grim, Travis W., Ghosh, Sudeshna, Hsu, Ku-Lung, Cravatt, Benjamin F., Kinsey, Steven G., Lichtman, Aron H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Animals Cyclooxygenase (COX) Disease Models, Animal Endogenous cannabinoid (endocannabinoid) Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Fatty acid amide hydrolase Hyperalgesia - drug therapy Inflammation - drug therapy Inflammatory pain Male Mice Mice, Inbred C57BL Neuralgia - drug therapy Neuropathic pain Prostaglandin-Endoperoxide Synthases - drug effects Prostaglandins
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