Mutagenic and antimutagenic effects of Heterotheca inuloides
The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames...
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| Veröffentlicht in: | Scientific reports 2014-10, Vol.4 (1), p.6743, Article 6743 |
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| creator | Ruiz-Pérez, Nancy J. Arriaga-Alba, Myriam Sánchez-Navarrete, Jaime Camacho-Carranza, Rafael Hernández-Ojeda, Sandra Espinosa-Aguirre, Javier J. |
| description | The antioxidant and hepatoprotective effects of
Heterotheca inuloides
have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of
H. inuloides
extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of
H. inuloides
could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with
in vivo
systems will afford information about
H. inuloides
beneficial and detrimental properties. |
| doi_str_mv | 10.1038/srep06743 |
| format | Article |
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Heterotheca inuloides
have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of
H. inuloides
extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of
H. inuloides
could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with
in vivo
systems will afford information about
H. inuloides
beneficial and detrimental properties.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep06743</identifier><identifier>PMID: 25339199</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>2-Aminoanthracene ; 38/70 ; 631/208/325/2482 ; 631/67/68 ; 82/80 ; Ames test ; Antimutagenic Agents - administration & dosage ; Antimutagenic Agents - chemistry ; Antioxidants ; Antioxidants - chemistry ; Asteraceae - chemistry ; Benzo(a)pyrene ; Cancer ; Cytochrome P-450 CYP1A1 - genetics ; Cytochrome P450 ; Humanities and Social Sciences ; Information systems ; Liver ; multidisciplinary ; Mutagenesis - drug effects ; Mutagenicity ; Mutation ; Norfloxacin ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - genetics ; Polyamines ; Polyphenols ; Pyrene ; Quercetin ; Quercetin - administration & dosage ; Quercetin - chemistry ; Quercetin - genetics ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - genetics ; Science</subject><ispartof>Scientific reports, 2014-10, Vol.4 (1), p.6743, Article 6743</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Oct 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f63d17488f7196aa7c2b5067041a7abc8a9d28cb2bacdd7ec3ce3650895f0ce13</citedby><cites>FETCH-LOGICAL-c438t-f63d17488f7196aa7c2b5067041a7abc8a9d28cb2bacdd7ec3ce3650895f0ce13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,41118,42187,51574,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25339199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz-Pérez, Nancy J.</creatorcontrib><creatorcontrib>Arriaga-Alba, Myriam</creatorcontrib><creatorcontrib>Sánchez-Navarrete, Jaime</creatorcontrib><creatorcontrib>Camacho-Carranza, Rafael</creatorcontrib><creatorcontrib>Hernández-Ojeda, Sandra</creatorcontrib><creatorcontrib>Espinosa-Aguirre, Javier J.</creatorcontrib><title>Mutagenic and antimutagenic effects of Heterotheca inuloides</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The antioxidant and hepatoprotective effects of
Heterotheca inuloides
have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of
H. inuloides
extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of
H. inuloides
could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with
in vivo
systems will afford information about
H. inuloides
beneficial and detrimental properties.</description><subject>2-Aminoanthracene</subject><subject>38/70</subject><subject>631/208/325/2482</subject><subject>631/67/68</subject><subject>82/80</subject><subject>Ames test</subject><subject>Antimutagenic Agents - administration & dosage</subject><subject>Antimutagenic Agents - chemistry</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Asteraceae - chemistry</subject><subject>Benzo(a)pyrene</subject><subject>Cancer</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Cytochrome P450</subject><subject>Humanities and Social Sciences</subject><subject>Information systems</subject><subject>Liver</subject><subject>multidisciplinary</subject><subject>Mutagenesis - drug effects</subject><subject>Mutagenicity</subject><subject>Mutation</subject><subject>Norfloxacin</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - genetics</subject><subject>Polyamines</subject><subject>Polyphenols</subject><subject>Pyrene</subject><subject>Quercetin</subject><subject>Quercetin - administration & dosage</subject><subject>Quercetin - chemistry</subject><subject>Quercetin - genetics</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - genetics</subject><subject>Science</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkFtLAzEQhYMottQ--AdkwSeF1Vx2NwmIIMUbVHzR55DNTtot7aYmWcF_b6S1VAwMGWY-zhwOQqcEXxHMxHXwsMYVL9gBGlJclDlllB7u9QM0DmGB0yupLIg8RgNaMiaJlEN089JHPYOuNZnumlSxXe0mYC2YGDJnsyeI4F2cg9FZ2_VL1zYQTtCR1csA4-0_Qu8P92-Tp3z6-vg8uZvmpmAi5rZiDeGFEJYTWWnNDa3LZBkXRHNdG6FlQ4Wpaa1N03AwzACrSixkabEBwkbodqO77usVNAa66PVSrX270v5LOd2qv5uunauZ-1QFxZWoRBI43wp499FDiGrhet8lz4oIKQhnvKwSdbGhjHchxWp3FwhWP1mrXdaJPdu3tCN_k03A5QYIadXNwO-d_Kf2DflKiXU</recordid><startdate>20141023</startdate><enddate>20141023</enddate><creator>Ruiz-Pérez, Nancy J.</creator><creator>Arriaga-Alba, Myriam</creator><creator>Sánchez-Navarrete, Jaime</creator><creator>Camacho-Carranza, Rafael</creator><creator>Hernández-Ojeda, Sandra</creator><creator>Espinosa-Aguirre, Javier J.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20141023</creationdate><title>Mutagenic and antimutagenic effects of Heterotheca inuloides</title><author>Ruiz-Pérez, Nancy J. ; Arriaga-Alba, Myriam ; Sánchez-Navarrete, Jaime ; Camacho-Carranza, Rafael ; Hernández-Ojeda, Sandra ; Espinosa-Aguirre, Javier J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f63d17488f7196aa7c2b5067041a7abc8a9d28cb2bacdd7ec3ce3650895f0ce13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>2-Aminoanthracene</topic><topic>38/70</topic><topic>631/208/325/2482</topic><topic>631/67/68</topic><topic>82/80</topic><topic>Ames test</topic><topic>Antimutagenic Agents - administration & dosage</topic><topic>Antimutagenic Agents - chemistry</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Asteraceae - chemistry</topic><topic>Benzo(a)pyrene</topic><topic>Cancer</topic><topic>Cytochrome P-450 CYP1A1 - genetics</topic><topic>Cytochrome P450</topic><topic>Humanities and Social Sciences</topic><topic>Information systems</topic><topic>Liver</topic><topic>multidisciplinary</topic><topic>Mutagenesis - drug effects</topic><topic>Mutagenicity</topic><topic>Mutation</topic><topic>Norfloxacin</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - genetics</topic><topic>Polyamines</topic><topic>Polyphenols</topic><topic>Pyrene</topic><topic>Quercetin</topic><topic>Quercetin - administration & dosage</topic><topic>Quercetin - chemistry</topic><topic>Quercetin - genetics</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - genetics</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz-Pérez, Nancy J.</creatorcontrib><creatorcontrib>Arriaga-Alba, Myriam</creatorcontrib><creatorcontrib>Sánchez-Navarrete, Jaime</creatorcontrib><creatorcontrib>Camacho-Carranza, Rafael</creatorcontrib><creatorcontrib>Hernández-Ojeda, Sandra</creatorcontrib><creatorcontrib>Espinosa-Aguirre, Javier J.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz-Pérez, Nancy J.</au><au>Arriaga-Alba, Myriam</au><au>Sánchez-Navarrete, Jaime</au><au>Camacho-Carranza, Rafael</au><au>Hernández-Ojeda, Sandra</au><au>Espinosa-Aguirre, Javier J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagenic and antimutagenic effects of Heterotheca inuloides</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-10-23</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>6743</spage><pages>6743-</pages><artnum>6743</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The antioxidant and hepatoprotective effects of
Heterotheca inuloides
have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of
H. inuloides
extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of
H. inuloides
could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with
in vivo
systems will afford information about
H. inuloides
beneficial and detrimental properties.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25339199</pmid><doi>10.1038/srep06743</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2014-10, Vol.4 (1), p.6743, Article 6743 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 2-Aminoanthracene 38/70 631/208/325/2482 631/67/68 82/80 Ames test Antimutagenic Agents - administration & dosage Antimutagenic Agents - chemistry Antioxidants Antioxidants - chemistry Asteraceae - chemistry Benzo(a)pyrene Cancer Cytochrome P-450 CYP1A1 - genetics Cytochrome P450 Humanities and Social Sciences Information systems Liver multidisciplinary Mutagenesis - drug effects Mutagenicity Mutation Norfloxacin Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - genetics Polyamines Polyphenols Pyrene Quercetin Quercetin - administration & dosage Quercetin - chemistry Quercetin - genetics Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Science |
| title | Mutagenic and antimutagenic effects of Heterotheca inuloides |
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