Adverse Remodeling of the Electrophysiological Response to Ischemia–Reperfusion in Human Heart Failure Is Associated With Remodeling of Metabolic Gene Expression

BACKGROUND—Ventricular arrhythmias occur more frequently in heart failure during episodes of ischemia–reperfusion although the mechanisms underlying this in humans are unclear. We assessed, in explanted human hearts, the remodeled electrophysiological response to acute ischemia–reperfusion in heart...

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Veröffentlicht in:	Circulation. Arrhythmia and electrophysiology 2014-10, Vol.7 (5), p.875-882
Hauptverfasser:	Ng, Fu Siong, Holzem, Katherine M, Koppel, Aaron C, Janks, Deborah, Gordon, Fabiana, Wit, Andrew L, Peters, Nicholas S, Efimov, Igor R
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adult Aged Energy Metabolism - genetics Female Gene Expression Profiling - methods Gene Expression Regulation Heart Conduction System - metabolism Heart Conduction System - physiopathology Heart Failure - diagnosis Heart Failure - genetics Heart Failure - metabolism Heart Failure - physiopathology Humans Kinetics Male Middle Aged Myocardial Reperfusion Injury - diagnosis Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - physiopathology Oligonucleotide Array Sequence Analysis Recovery of Function
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