B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

Naive B and T cells exist in discrete zones in lymph nodes. Turley and colleagues demonstrate that a distinct subset of fibroblastic reticular cells reside in B cell zones, where they sustain B cell survival by providing BAFF. Fibroblastic reticular cells (FRCs) are known to inhabit T cell–rich area...

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Veröffentlicht in:	Nature immunology 2014-10, Vol.15 (10), p.973-981
Hauptverfasser:	Cremasco, Viviana, Woodruff, Matthew C, Onder, Lucas, Cupovic, Jovana, Nieves-Bonilla, Janice M, Schildberg, Frank A, Chang, Jonathan, Cremasco, Floriana, Harvey, Christopher J, Wucherpfennig, Kai, Ludewig, Burkhard, Carroll, Michael C, Turley, Shannon J
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 14/19 14/63 14/69 38/77 38/88 631/250/2152 64/60 Adaptive immunity Animals Antiviral agents B cells B-Cell Activating Factor - immunology B-Cell Activating Factor - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedicine BLyS protein Cell Movement - immunology Cell survival Cell Survival - immunology Cell viability Cells, Cultured Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Disease susceptibility Fibroblasts - immunology Fibroblasts - metabolism Flow Cytometry Follicles Homeostasis Homeostasis - immunology Humoral immunity Identity Immune response Immunity, Humoral - immunology Immunology Infectious Diseases Luminescent Proteins - genetics Luminescent Proteins - metabolism Lymph nodes Lymph Nodes - immunology Lymph Nodes - metabolism Lymphocytes Lymphocytes B Lymphocytes T Male Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal Physiological aspects Properties Regulation Spleen T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism
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