Ligand binding to the FeMo-cofactor: Structures of CO-bound and reactivated nitrogenase

The mechanism of nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrates bind to the active site.We report a crystal structure of carbon monoxide (CO)–inhibited nitrogenase molybdenum-iron (MoFe)–protein at 1.50 angstrom resolution, which reveals a CO mo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2014-09, Vol.345 (6204), p.1620-1623
Hauptverfasser:	Spatzal, Thomas, Perez, Kathryn A., Einsle, Oliver, Howard, James B., Rees, Douglas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ammonia Atmospheric chemistry Binding Biomolecules biosynthesis Carbon monoxide Carbon Monoxide - chemistry Catalytic Domain Chemical bonds Coordination compounds Crystal structure Crystallography, X-Ray Earth atmosphere Enzyme Activation Enzymes Inhibitors Ligands metalloproteins Molybdoferredoxin - antagonists & inhibitors Molybdoferredoxin - chemistry Nitrogen Nitrogen Fixation nitrogenase Protein Binding Substrates Sulfur - chemistry
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