Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids
Research investigating lipid membrane curvature generation and sensing is a rapidly developing frontier in membrane physical chemistry and biophysics. The fast recent progress is based on the discovery of a plethora of proteins involved in coupling membrane shape to cellular membrane function, the d...
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| Veröffentlicht in: | Annual review of physical chemistry 2011-01, Vol.62 (1), p.483-506 |
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| container_title | Annual review of physical chemistry |
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| creator | Baumgart, Tobias Capraro, Benjamin R Zhu, Chen Das, Sovan L |
| description | Research investigating lipid membrane curvature generation and sensing is a rapidly developing frontier in membrane physical chemistry and biophysics. The fast recent progress is based on the discovery of a plethora of proteins involved in coupling membrane shape to cellular membrane function, the design of new quantitative experimental techniques to study aspects of membrane curvature, and the development of analytical theories and simulation techniques that allow a mechanistic interpretation of quantitative measurements. The present review first provides an overview of important classes of membrane proteins for which function is coupled to membrane curvature. We then survey several mechanisms that are assumed to underlie membrane curvature sensing and generation. Finally, we discuss relatively simple thermodynamic/mechanical models that allow quantitative interpretation of experimental observations. |
| doi_str_mv | 10.1146/annurev.physchem.012809.103450 |
| format | Article |
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| ispartof | Annual review of physical chemistry, 2011-01, Vol.62 (1), p.483-506 |
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| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Cell Membrane - chemistry Cell Membrane - metabolism Hydrophobic and Hydrophilic Interactions Lipids Measurement Mechanics Membrane Fluidity - physiology Membrane Lipids - chemistry Membrane Lipids - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Models, Molecular Proteins Simulation Thermodynamics |
| title | Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids |
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