Interactions of “Bora-Penicilloates” with Serine β‑Lactamases and DD-Peptidases

Specific boronic acids are generally powerful tetrahedral intermediate/transition state analogue inhibitors of serine amidohydrolases. This group of enzymes includes bacterial β-lactamases and DD-peptidases where there has been considerable development of boronic acid inhibitors. This paper describe...

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Veröffentlicht in:	Biochemistry (Easton) 2014-10, Vol.53 (41), p.6530-6538
Hauptverfasser:	Dzhekieva, Liudmila, Adediran, S. A, Pratt, R. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation - drug effects Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - metabolism beta-Lactamase Inhibitors - chemistry beta-Lactamase Inhibitors - metabolism beta-Lactamase Inhibitors - pharmacology beta-Lactamases - chemistry beta-Lactamases - metabolism Biocatalysis - drug effects Boronic Acids - chemistry Boronic Acids - metabolism Boronic Acids - pharmacology Catalytic Domain Drug Design Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - metabolism Kinetics Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - metabolism Models, Molecular Molecular Conformation Penicillanic Acid - analogs & derivatives Penicillanic Acid - chemistry Penicillanic Acid - metabolism Penicillanic Acid - pharmacology Penicillin-Binding Proteins - antagonists & inhibitors Penicillin-Binding Proteins - chemistry Penicillin-Binding Proteins - metabolism Serine - chemistry Serine Endopeptidases - chemistry Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - metabolism Serine Proteinase Inhibitors - pharmacology
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