Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade

Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein-coupled receptors (LPA1-6). Recently, we reported that abrogation of LPA receptor 1 (LPA1) ameliorated murine collagen-induced arthritis, probably via inhibition of inflammatory cell migration, Th17 differentiation and osteocla...

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Veröffentlicht in:	Arthritis research & therapy 2014-10, Vol.16 (5), p.461, Article 461
Hauptverfasser:	Miyabe, Yoshishige, Miyabe, Chie, Iwai, Yoshiko, Yokoyama, Waka, Sekine, Chiyoko, Sugimoto, Kazutaka, Harigai, Masayoshi, Miyasaka, Masayuki, Miyasaka, Nobuyuki, Nanki, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analysis Animals Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Cell Movement - drug effects Cell Proliferation - drug effects Cell Proliferation - genetics Cells, Cultured CHO Cells Cricetinae Cricetulus Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Gene Expression - drug effects Humans Inflammation Mediators - metabolism Interleukins Isoxazoles - pharmacology Leukocytes - drug effects Lysophospholipids - pharmacology Middle Aged Physiological aspects Propionates - pharmacology Receptors, Lysophosphatidic Acid - antagonists & inhibitors Receptors, Lysophosphatidic Acid - genetics Receptors, Lysophosphatidic Acid - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Signal Transduction - genetics Synovial Membrane - metabolism Synovial Membrane - pathology
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