LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers

Leukaemia inhibitory factor (LIF) has been recently identified as a p53 target gene, which mediates the role of p53 in maternal implantation under normal physiological conditions. Here we report that LIF is a negative regulator of p53; LIF downregulates p53 protein levels and function in human color...

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Veröffentlicht in:	Nature communications 2014-10, Vol.5 (1), p.5218-5218, Article 5218
Hauptverfasser:	Yu, Haiyang, Yue, Xuetian, Zhao, Yuhan, Li, Xiaoyan, Wu, Lihua, Zhang, Cen, Liu, Zhen, Lin, Kevin, Xu-Monette, Zijun Y., Young, Ken H., Liu, Juan, Shen, Zhiyuan, Feng, Zhaohui, Hu, Wenwei
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 38 38/89 631/67/1059/2326 631/67/1504/1885 631/80/86 64/60 82/1 82/51 96/109 96/31 96/95 Animals Apoptosis Cell Line, Tumor Cell Survival Cellular Senescence Cohort Studies Colorectal cancer Colorectal Neoplasms - metabolism Down-Regulation Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic Genes Humanities and Social Sciences Humans Inhibitor of Differentiation Protein 1 - metabolism Leukemia Leukemia Inhibitory Factor - metabolism Male Mice Mice, Inbred BALB C Mice, Nude multidisciplinary Neoplasm Transplantation Oligonucleotide Array Sequence Analysis Proteins Proto-Oncogene Proteins c-mdm2 - metabolism Regulation Science Science (multidisciplinary) STAT3 Transcription Factor - metabolism Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors
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