The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics

Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. For EEG study...

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Veröffentlicht in:	Basic and Clinical Neuroscience 2013, Vol.4 (1), p.31-35
Hauptverfasser:	Moghimi, Ali, Mollazadeh, Samaneh, Rassouli, Fatemeh Behnam, Shiee, Reza, Khalilzade, Mohammad Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	4 aminobutyric acid metabolism absence Absence epilepsy animal experiment animal model animal tissue brain cortex causal attribution Ciprofloxacin controlled study ECG abnormality EEG electrode implant electroencephalography Epilepsy experimental rat GABAergic system Glutamic acid receptors (ionotropic) Injection Magnesium male N-Methyl-D-aspartic acid receptors neuropathology neurotoxicity nonhuman pathophysiology rat Research Papers risk assessment seizure susceptibility Seizures spike wave Wag/rij
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