Dosimetric and geometric evaluation of the use of deformable image registration in adaptive intensity-modulated radiotherapy for head-and-neck cancer

The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and...

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Veröffentlicht in:Journal of radiation research 2014-09, Vol.55 (5), p.1002-1008
Hauptverfasser: Eiland, R.B., Maare, C., Sjöström, D., Samsøe, E., Behrens, C.F.
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container_issue 5
container_start_page 1002
container_title Journal of radiation research
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creator Eiland, R.B.
Maare, C.
Sjöström, D.
Samsøe, E.
Behrens, C.F.
description The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and a cone beam CT (CBCT). The CBCT was acquired on the same day (±1 d) as the ReCT (i.e. at Fraction 17, 18, 23, 24 or 29). The ReCT served as ground truth. A deformed CT (dCT) with structures was created by deforming the pCT to the CBCT. The geometrical comparison was based on the volumes of the deformed, and the manually delineated structures on the ReCT. Likewise, the center of mass shift (CMS) and the Dice similarity coefficient were determined. The dosimetric comparison was performed by recalculating the initial treatment plan on the dCT and the ReCT. Dose–volume histogram (DVH) points and a range of conformity measures were used for the evaluation. We found a significant difference in the median volume of the dCT relative to that of the ReCT. Median CMS values were ∼2–5 mm, except for the spinal cord, where the median CMS was 8 mm. Dosimetric evaluation of target structures revealed small differences, while larger differences were observed for organs at risk. The deformed structures cannot fully replace manually delineated structures. Based on both geometrical and dosimetrical measures, there is a tendency for the dCT to overestimate the need for replanning, compared with the ReCT.
doi_str_mv 10.1093/jrr/rru044
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Maare, C. ; Sjöström, D. ; Samsøe, E. ; Behrens, C.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-9cc639179cec3d13b2a1e560d8c2143d793362494ce7c175211523b5fa02fcca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adaptive algorithms</topic><topic>Algorithms</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Deformation</topic><topic>Formability</topic><topic>Ground truth</topic><topic>Head and Neck Neoplasms - diagnostic imaging</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Image registration</topic><topic>Oncology</topic><topic>Patient Positioning - methods</topic><topic>Radiographic Image Interpretation, Computer-Assisted - methods</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Conformal - methods</topic><topic>Radiotherapy, Image-Guided - methods</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Similarity</topic><topic>Software</topic><topic>Spinal cord</topic><topic>Subtraction Technique</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eiland, R.B.</creatorcontrib><creatorcontrib>Maare, C.</creatorcontrib><creatorcontrib>Sjöström, D.</creatorcontrib><creatorcontrib>Samsøe, E.</creatorcontrib><creatorcontrib>Behrens, C.F.</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eiland, R.B.</au><au>Maare, C.</au><au>Sjöström, D.</au><au>Samsøe, E.</au><au>Behrens, C.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric and geometric evaluation of the use of deformable image registration in adaptive intensity-modulated radiotherapy for head-and-neck cancer</atitle><jtitle>Journal of radiation research</jtitle><addtitle>J Radiat Res</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>55</volume><issue>5</issue><spage>1002</spage><epage>1008</epage><pages>1002-1008</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. 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Dosimetric evaluation of target structures revealed small differences, while larger differences were observed for organs at risk. The deformed structures cannot fully replace manually delineated structures. Based on both geometrical and dosimetrical measures, there is a tendency for the dCT to overestimate the need for replanning, compared with the ReCT.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>24907340</pmid><doi>10.1093/jrr/rru044</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Adaptive algorithms
Algorithms
Analysis
Cancer
Deformation
Formability
Ground truth
Head and Neck Neoplasms - diagnostic imaging
Head and Neck Neoplasms - radiotherapy
Humans
Image registration
Oncology
Patient Positioning - methods
Radiographic Image Interpretation, Computer-Assisted - methods
Radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Conformal - methods
Radiotherapy, Image-Guided - methods
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Similarity
Software
Spinal cord
Subtraction Technique
Tomography, X-Ray Computed - methods
title Dosimetric and geometric evaluation of the use of deformable image registration in adaptive intensity-modulated radiotherapy for head-and-neck cancer
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