Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

Epithelial to mesenchymal transition (EMT) is a key process in embryonic development and has been associated with cancer metastasis and drug resistance. For example, in EGFR mutated non-small cell lung cancers (NSCLC), EMT has been associated with acquired resistance to the EGFR inhibitor erlotinib....

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Veröffentlicht in:	Oncotarget 2014-09, Vol.5 (17), p.7328-7341
Hauptverfasser:	Wilson, Catherine, Nicholes, Katrina, Bustos, Daisy, Lin, Eva, Song, Qinghua, Stephan, Jean-Philippe, Kirkpatrick, Donald S, Settleman, Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell Survival - drug effects Dasatinib Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - physiology Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Erlotinib Hydrochloride Flow Cytometry Fluorescent Antibody Technique Focal Adhesion Kinase 1 - metabolism Genes, erbB-1 Humans Immunoblotting Lung Neoplasms - metabolism Mice Mice, Nude Mutation Priority Research Paper Pyrimidines - pharmacology Quinazolines - pharmacology Receptor, Epidermal Growth Factor - genetics Signal Transduction - drug effects Signal Transduction - physiology src-Family Kinases - metabolism Thiazoles - pharmacology Xenograft Model Antitumor Assays
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