Antibiotic-containing polymers for localized, sustained drug delivery
Many currently used antibiotics suffer from issues such as systemic toxicity, short half-life, and increased susceptibility to bacterial resistance. Although most antibiotic classes are administered systemically through oral or intravenous routes, a more efficient delivery system is needed. This rev...
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| Veröffentlicht in: | Advanced drug delivery reviews 2014-11, Vol.78, p.77-87 |
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| container_title | Advanced drug delivery reviews |
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| creator | Stebbins, Nicholas D. Ouimet, Michelle A. Uhrich, Kathryn E. |
| description | Many currently used antibiotics suffer from issues such as systemic toxicity, short half-life, and increased susceptibility to bacterial resistance. Although most antibiotic classes are administered systemically through oral or intravenous routes, a more efficient delivery system is needed. This review discusses the chemical conjugation of antibiotics to polymers, achieved by forming covalent bonds between antibiotics and a pre-existing polymer or by developing novel antibiotic-containing polymers. Through conjugating antibiotics to polymers, unique polymer properties can be taken advantage of. These polymeric antibiotics display controlled, sustained drug release and vary in antibiotic class type, synthetic method, polymer composition, bond lability, and antibacterial activity. The polymer synthesis, characterization, drug release, and antibacterial activities, if applicable, will be presented to offer a detailed overview of each system.
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| doi_str_mv | 10.1016/j.addr.2014.04.006 |
| format | Article |
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[Display omitted]</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Bacteria</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - microbiology</subject><subject>Biocompatible</subject><subject>Bonding</subject><subject>Controlled release</subject><subject>Covalent bonds</subject><subject>Delayed-Action Preparations</subject><subject>Drug Delivery Systems</subject><subject>Drug Design</subject><subject>Drug Liberation</subject><subject>Drug Resistance, Bacterial</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Localized delivery antibiotics</subject><subject>Polymer conjugates</subject><subject>Polymers</subject><subject>Polymers - chemistry</subject><subject>Sustained release</subject><subject>Toxicity</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1r3DAQhkVJaDZp_0APwccc6s1ItvUBpRBCviCQSwK9CVkab7V4rY1kL2x-fbVsGtJLCQzMYZ55mXlfQr5RmFOg_Hw5N87FOQNazyEX8E9kRqVgpWSqPiCzDKmyBvXriByntASgTHD4TI5YLRoqpZyRq4th9K0Po7elDcNo_OCHRbEO_XaFMRVdiEUfrOn9C7rvRZrSDkFXuDgtCoe932DcfiGHnekTfn3tJ-Tp-urx8ra8f7i5u7y4L22j6Fh2itXYCIoCGTgn2tZZ1ThDBaXQOF6DVNKpCm0lK1DIKAPbuVYw0VUU2-qE_Nzrrqd2hc7iMEbT63X0KxO3Ohiv_50M_rdehI2us0kKZBY4exWI4XnCNOqVTxb73gwYpqQp50ryRgJ8BIVKctawjLI9amNIKWL3dhEFvYtKL_UuKr2LSkMu4Hnp9P0vbyt_s8nAjz2A2dGNx6iT9ThYdD6iHbUL_n_6fwAqpqZn</recordid><startdate>20141130</startdate><enddate>20141130</enddate><creator>Stebbins, Nicholas D.</creator><creator>Ouimet, Michelle A.</creator><creator>Uhrich, Kathryn E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>JG9</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20141130</creationdate><title>Antibiotic-containing polymers for localized, sustained drug delivery</title><author>Stebbins, Nicholas D. ; Ouimet, Michelle A. ; Uhrich, Kathryn E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-f924e571e7e20dd7bbdc95da171105d640898d93ec38309e2120cfdb727f31eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Bacteria</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - microbiology</topic><topic>Biocompatible</topic><topic>Bonding</topic><topic>Controlled release</topic><topic>Covalent bonds</topic><topic>Delayed-Action Preparations</topic><topic>Drug Delivery Systems</topic><topic>Drug Design</topic><topic>Drug Liberation</topic><topic>Drug Resistance, Bacterial</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Localized delivery antibiotics</topic><topic>Polymer conjugates</topic><topic>Polymers</topic><topic>Polymers - chemistry</topic><topic>Sustained release</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stebbins, Nicholas D.</creatorcontrib><creatorcontrib>Ouimet, Michelle A.</creatorcontrib><creatorcontrib>Uhrich, Kathryn E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stebbins, Nicholas D.</au><au>Ouimet, Michelle A.</au><au>Uhrich, Kathryn E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic-containing polymers for localized, sustained drug delivery</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2014-11-30</date><risdate>2014</risdate><volume>78</volume><spage>77</spage><epage>87</epage><pages>77-87</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Many currently used antibiotics suffer from issues such as systemic toxicity, short half-life, and increased susceptibility to bacterial resistance. Although most antibiotic classes are administered systemically through oral or intravenous routes, a more efficient delivery system is needed. This review discusses the chemical conjugation of antibiotics to polymers, achieved by forming covalent bonds between antibiotics and a pre-existing polymer or by developing novel antibiotic-containing polymers. Through conjugating antibiotics to polymers, unique polymer properties can be taken advantage of. These polymeric antibiotics display controlled, sustained drug release and vary in antibiotic class type, synthetic method, polymer composition, bond lability, and antibacterial activity. The polymer synthesis, characterization, drug release, and antibacterial activities, if applicable, will be presented to offer a detailed overview of each system.
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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2014-11, Vol.78, p.77-87 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibiotics Antiinfectives and antibacterials Bacteria Bacterial Infections - drug therapy Bacterial Infections - microbiology Biocompatible Bonding Controlled release Covalent bonds Delayed-Action Preparations Drug Delivery Systems Drug Design Drug Liberation Drug Resistance, Bacterial Half-Life Humans Localized delivery antibiotics Polymer conjugates Polymers Polymers - chemistry Sustained release Toxicity |
| title | Antibiotic-containing polymers for localized, sustained drug delivery |
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