Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

Neutrophil extracellular traps (NETs) have been described as a fundamental innate immune defence mechanism. They consist of a nuclear DNA backbone associated with different antimicrobial peptides (AMPs) which are able to engulf and kill pathogens. The AMP LL-37, a member of the cathelicidin family,...

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Veröffentlicht in:	Journal of innate immunity 2014-01, Vol.6 (6), p.860-868
Hauptverfasser:	Neumann, Ariane, Völlger, Lena, Berends, Evelien T.M., Molhoek, E. Margo, Stapels, Daphne A.C., Midon, Marika, Friães, Ana, Pingoud, Alfred, Rooijakkers, Suzan H.M., Gallo, Richard L., Mörgelin, Matthias, Nizet, Victor, Naim, Hassan Y., von Köckritz-Blickwede, Maren
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial Cationic Peptides Antimicrobial peptides Bacterial Proteins - immunology Bacterial Proteins - metabolism Basic Medicine Cathelicidin Cathelicidins - immunology Cathelicidins - metabolism Extracellular Traps - immunology Extracellular Traps - metabolism Extracellular Traps - microbiology Female Humans Immunologi inom det medicinska området Immunology in the medical area Male Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Micrococcal Nuclease - immunology Micrococcal Nuclease - metabolism Neutrophil extracellular traps Neutrophils - immunology Neutrophils - metabolism Nucleases Research Article Staphylococcus aureus - enzymology Staphylococcus aureus - immunology
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